奥索地平
奥索地平名称
[ CAS 号 ]:
90729-41-2
[ 中文名 ]:
奥索地平
[ 英文名 ]:
Oxodipine
[英文别名 ]:
- Oxodipinum
- IQB-837-V
- Oxodipino [Spanish]
- Oxodipinum [Latin]
- Oxodipine [INN]
- OXODIPINE
- Oxodipino
奥索地平物理化学性质
[ 密度 ]:
1.247g/cm3
[ 沸点 ]:
470ºC at 760 mmHg
[ 分子式 ]:
C19H21NO6
[ 分子量 ]:
359.37300
[ 闪点 ]:
238ºC
[ 精确质量 ]:
359.13700
[ PSA ]:
83.09000
[ LogP ]:
2.71500
[ 折射率 ]:
1.552
奥索地平毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- US7968500
- CHEMICAL NAME :
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-, ethyl methyl ester
- CAS REGISTRY NUMBER :
- 90729-41-2
- LAST UPDATED :
- 199406
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H21-N-O6
- MOLECULAR WEIGHT :
- 359.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,633,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 54(2),40,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2160 mg/kg/13W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Endocrine - other changes Endocrine - changes in adrenal weight
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 20,549,1992
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