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月桂醇聚氧乙烯醚

月桂醇聚氧乙烯醚用途

Polidocanol 是一种硬化剂,可用于肢体和食管静脉曲张和毛细血管扩张的研究。

月桂醇聚氧乙烯醚名称

[ CAS 号 ]:
9002-92-0

[ 中文名 ]:
月桂醇聚氧乙烯醚

[ 英文名 ]:
Polyoxyethylene lauryl ether

[中文别名 ]:

[英文别名 ]:

depeg
EINECS 500-002-6
la7
g3711
ped
bl9
do9
g3707
polyoxethyleneglycol-23 lauryl ether
bl9ex

月桂醇聚氧乙烯醚生物活性

[ 描述 ]:

Polidocanol 是一种硬化剂,可用于肢体和食管静脉曲张和毛细血管扩张的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[体内研究]

聚二醇(0.5％,1％和2％)导致比四环素显着更多的粘连,而稀释的聚多卡醇的作用类似于大鼠中四环素的作用。聚乙二醇浓度较高,0.5％,1％和2％比稀释的聚多卡醇或四环素对胸膜固定术更有效[1]。

[参考文献]

[1]. Cetin B, et al. Polidocanol at different concentrations for pleurodesis in rats. Surg Today. 2005;35(12):1066-9.

[相关活性小分子]

月桂醇聚氧乙烯醚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
960.0±60.0 °C at 760 mmHg

[ 熔点 ]:
41-45 °C(lit.)

[ 分子式 ]:
(C₂H₄O)nC₁₂H₂₆O

[ 分子量 ]:
1199.543

[ 闪点 ]:
534.4±32.9 °C

[ 精确质量 ]:
1198.801270

[ PSA ]:
232.52000

[ LogP ]:
-2.83

[ 外观性状 ]:
透明油性液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.465

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
可溶

月桂醇聚氧乙烯醚MSDS

详细MSDS(安全技术说明书)

月桂醇聚氧乙烯醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR5990000

CHEMICAL NAME :: Dodecyl alcohol condensed with 23 moles ethylene oxide

CAS REGISTRY NUMBER :: 9002-92-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

WISWESSER LINE NOTATION :: T3OTJ 23 &Q12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPCOAH Soap, Perfumery & Cosmetics. (London, UK) V.8(7)-48(2), 1935-75. Volume(issue)/page/year: 38,47,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APRCAS American Perfumer and Cosmetics. (Oak Park, IL) V.77-86, 1962-71. For publisher information, see CSPEAX. Volume(issue)/page/year: 77,35,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1179 No. of Facilities: 3288 (estimated) No. of Industries: 33 No. of Occupations: 37 No. of Employees: 43764 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1179 No. of Facilities: 5821 (estimated) No. of Industries: 32 No. of Occupations: 40 No. of Employees: 104035 (estimated) No. of Female Employees: 60645 (estimated)

月桂醇聚氧乙烯醚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
26-39-37/39-36/37/39-36-24/25

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MD0875000

[ 海关编码 ]:
34021300

月桂醇聚氧乙烯醚制备

1.1 mol C₁₂_～₁₈脂肪醇在固碱催化下与20 mol环氧乙烷缩合。反应在管式反应器中进行。反应器的前部分为264根5.5 m长、16 mm口径的钢管，后部分为58根长5.5 m、25.4 mm的钢管组成。各管间用U形环连成串联形式。其中16 mm的管共长1 448 mm，25.4 mm管共长318 mm。16 mm管的前部为预热区，其余部分为反应区，25.4 mm的管全部为浸渍区。全部管放在一个密封的水槽中。通过管和控制器维持进入水槽中一定数量的热水，反应室内的温度维持在120～140℃。此温度由压力控制调节器控制。水槽一端的盖上有许多环氧乙烷进料口，进料口与环氧乙烷贮罐相连。
具体操作是将固体催化剂加入供料罐中，熔化的脂肪醇用泵打入供料罐中，两种原料在供料罐中混匀后打入反应室的预热部分。当温度升至50～70℃时，环氧乙烷从贮罐压入各加料口进入反应室。经取料测浊点（1%水溶液）达到75℃左右反应终止。反应液进入中和釜，用冰醋酸调pH值至5.0～7.0，然后加入双氧水漂白脱色，冷却到50℃以下，放料包装即为成品。

月桂醇聚氧乙烯醚海关

[ 海关编码 ]: 34021300

月桂醇聚氧乙烯醚文献

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

Antimicrobial Nanoemulsion Formulation with Improved Penetration of Foliar Spray through Citrus Leaf Cuticles to Control Citrus Huanglongbing.

PLoS ONE 10 , e0133826, (2015)

Huanglongbing (HLB) is the most serious disease affecting the citrus industry worldwide to date. The causal agent, Candidatus Liberibacter asiaticus (Las), resides in citrus phloem, which makes it dif...

Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.

Bioorg. Med. Chem. Lett. 18 , 4578-80, (2008)

A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOL...

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