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1,4-雄烯二酮

1,4-雄烯二酮用途

【用途一】
用作甾体激素的中间体
【用途二】
甾体激素类药物的中间体。

1,4-雄烯二酮名称

[ CAS 号 ]:
897-06-3

[ 中文名 ]:
雄甾-1,4-二烯-3,17-二酮

[ 英文名 ]:
androsta-1,4-diene-3,17-dione

[中文别名 ]:

[英文别名 ]:

ANDROSTADIENEDIONE
Androsta-1, 4-diene-3, 17-dione
EINECS 212-977-2
ANDROSTADIENDIONE (ADD)
Androsta-1,4-diene-3,17-dione
1,4-ANDROSTADIENEDIONE
MFCD00003614
ANDROSTANE-1,4-DIENE-3,17-DIONE
1,4-ANDROSTADIENE-3,17-DIONE(ADD)
ANDROSTADIENDIONE

1,4-雄烯二酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
434.2±45.0 °C at 760 mmHg

[ 熔点 ]:
138-139 °C(lit.)

[ 分子式 ]:
C₁₉H₂₄O₂

[ 分子量 ]:
284.393

[ 闪点 ]:
162.1±25.7 °C

[ 精确质量 ]:
284.177643

[ PSA ]:
34.14000

[ LogP ]:
2.92

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
Refrigerator

1,4-雄烯二酮MSDS

1,4-雄烯二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV7988000

CHEMICAL NAME :: Androsta-1,4-diene-3,17-dione

CAS REGISTRY NUMBER :: 897-06-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H24-O2

MOLECULAR WEIGHT :: 284.43

WISWESSER LINE NOTATION :: L E5 B666 FV OV AHTTT&J A1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 mg/kg

SEX/DURATION :: female 15-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 17,118,1956

1,4-雄烯二酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BV7988000

[ 海关编码 ]:
29372900

1,4-雄烯二酮合成路线

1,4-雄烯二酮制备

可用植物甾酸或胆甾醇以微生物转化法去除17-位侧链制取。

1,4-雄烯二酮海关

[ 海关编码 ]: 29372900

1,4-雄烯二酮文献

Development of a quantitative method for the simultaneous analysis of the boar taint compounds androstenone, skatole and indole in porcine serum and plasma by means of ultra-high performance liquid chromatography coupled to high resolution mass spectrometry.

Food Chem. 187 , 120-9, (2015)

Boar taint is an off-odour occurring while heating meat or fat from boars. A method detecting the three compounds (androstenone, skatole and indole) simultaneously in blood would offer substantial adv...

Cholesterol assimilation and biotransformation by Lactobacillus helveticus.

Biotechnol. Lett. 34(1) , 103-7, (2012)

Lactobacillus helveticus, grown at 37°C in MRS medium supplemented with 3 mM cholesterol, assimilated all the cholesterol in 42 h having 68 U mg(-1) of intracellular cholesterol oxidase activity. The ...

Evaluation of urinary excretion of androgens conjugated to cysteine in human pregnancy by mass spectrometry.

J. Steroid Biochem. Mol. Biol. 139 , 192-200, (2014)

Alterations in the maternal excretion of steroids during pregnancy are not restricted to the production of progesterone and estriol by the fetoplacental unit. Although there is a lack of longitudinal ...

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