邻苯二甲酸

邻苯二甲酸用途

Phthalic acid 是邻苯二甲酸酯 (PAE) 的最终常见代谢形式 (metabolite)。Phthalic acid 可用于合成试剂,例如间苯二甲酸 (IPA) 和对苯二甲酸 (TPA)。Phthalic acid 在邻苯二甲酸酯增塑剂的制备中具有广泛的应用。

邻苯二甲酸名称

[ CAS 号 ]:
88-99-3

[ 中文名 ]:
邻苯二甲酸

[ 英文名 ]:
Phthalic acid

[中文别名 ]:

[英文别名 ]:

Dihydrogen benzene-1,2-dicarboxylate
Hydrogen phthalate
o-Phthalic acid
Phthalic acid
EINECS 201-873-2
1,2-Benzenedicarboxylate, dihydrogen salt
o-Dicarboxybenzene
1,2-Benzenedicarboxylic acid
ortho-phthalic acid
QVR BVQ

邻苯二甲酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

IC50: metabolite of PAEs[1]

[参考文献]

[1]. Du Yeon Bang, et al.Toxicological Characterization of Phthalic Acid. Toxicol Res 2011;27:191−203

邻苯二甲酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
378.3±25.0 °C at 760 mmHg

[ 熔点 ]:
210-211 °C (dec.)(lit.)

[ 分子式 ]:
C₈H₆O₄

[ 分子量 ]:
166.131

[ 闪点 ]:
196.7±19.7 °C

[ 精确质量 ]:
166.026611

[ PSA ]:
74.60000

[ LogP ]:
0.81

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
7 g/L (25 ºC)

邻苯二甲酸MSDS

邻苯二甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH9625000

CHEMICAL NAME :: Phthalic acid

CAS REGISTRY NUMBER :: 88-99-3

BEILSTEIN REFERENCE NO. :: 0608199

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H6-O4

MOLECULAR WEIGHT :: 166.14

WISWESSER LINE NOTATION :: QVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(8),12,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,711,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 49,471,1942 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 102 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(8),12,1967 *** REVIEWS *** TOXICOLOGY REVIEW BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59185 No. of Facilities: 106 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 2321 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59185 No. of Facilities: 1480 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 19693 (estimated) No. of Female Employees: 2861 (estimated)

邻苯二甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TH9625000

[ 海关编码 ]:
2917399090

邻苯二甲酸合成路线

邻苯二甲酸上下游产品

邻苯二甲酸上游产品

邻苯二甲酸下游产品

邻苯二甲酸制备

1.邻苯二甲酸酐水解制得。

2.将邻苯二甲酸酐加到60℃水中，边搅拌边加入氨水至ph值为8，脱色过滤后，用盐酸酸化，所得结晶经水洗合格后，即为成品。过程反应式：

3. 烟草：BU，26。

邻苯二甲酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

邻苯二甲酸文献

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals.

J. Colloid. Interface Sci. 457 , 298-306, (2015)

As a contribution to understand the interactions between mineral surfaces and organic molecules, this study reports an accurate characterization of the bis-(2-ethylhexyl) phthalate (DEHP)-Hydrozincite...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Comparative evaluation of five plant extracts and juices for nanoiron synthesis and application for hexavalent chromium reduction.

Sci. Total Environ. 539 , 105-13, (2015)

The effectiveness of five plant extracts and juices, i.e. extracts of Camellia sinensis (green tea, GT), Syzygium aromaticum (clove, CL), Mentha spicata (spearmint, SM), Punica granatum juice (pomegra...

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