邻硝基苯酚

邻硝基苯酚用途

【用途一】
用于医药、染料工业，也用作分析试剂
【用途二】
用作医药、染料的中间体，也用作单色pH指示剂
【用途三】
用作分析试剂，也用于有机合成
【用途四】
用作医药、染料、橡胶助剂、感光材料等有机合成的中间体。亦可用作单色pH值指示剂。
【用途五】
测定葡萄糖和钾。有机合成。酸碱指示剂。pH5.0-7.0(无色-黄色),但变化不明显且无二氧化碳存在)。
【用途六】
用作医药、染料、橡胶助剂、感光材料等有机合成的中间体。亦可用作单色pH值指示剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

邻硝基苯酚名称

[ CAS 号 ]:
88-75-5

[ 中文名 ]:
邻硝基苯酚

[ 英文名 ]:
o-Nitrophenol

[中文别名 ]:

[英文别名 ]:

2-nitro-1-hydroxybenzene
o-Nitrofenol
Phenol,o-nitro
2-nitro-pheno
ortho-nitrophenol
EINECS 201-857-5
O-NITROPHENOL
MFCD00011688
o-nitro-pheno
2--nitrophenol

邻硝基苯酚物理化学性质

[ 密度 ]:
1.495

[ 沸点 ]:
214-216 °C

[ 熔点 ]:
43-45 °C

[ 分子式 ]:
C₆H₅NO₃

[ 分子量 ]:
139.10900

[ 闪点 ]:
108 °C

[ 精确质量 ]:
139.02700

[ PSA ]:
66.05000

[ LogP ]:
1.82360

[ 外观性状 ]:
黄色至棕色晶体

[ 蒸汽压 ]:
1 mm Hg ( 49.3 °C)

[ 折射率 ]:
1.5723 (50ºC)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong bases, strong oxidizing agents.

[ 水溶解性 ]:
2 g/L (25 ºC)

邻硝基苯酚MSDS

详细MSDS(安全技术说明书)

邻硝基苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM2100000

CHEMICAL NAME :: Phenol, o-nitro-

CAS REGISTRY NUMBER :: 88-75-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H5-N-O3

MOLECULAR WEIGHT :: 139.12

WISWESSER LINE NOTATION :: WNR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 334 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year: 8,145,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - coma

REFERENCE :: RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 16,449,1896

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1297 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-72-62,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 378 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,675,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >7940 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,74,1990

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - coma

REFERENCE :: RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 16,449,1896

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 50950 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 132 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 50950 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 80 (estimated)

邻硝基苯酚安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R33

[ 安全声明 (欧洲) ]:
S26-S61-S45-S36/37-S16-S7-S36

[ 危险品运输编码 ]:
UN 1663 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
SM2100000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2908999090

邻硝基苯酚合成路线

详细合成路线

邻硝基苯酚上下游产品

邻硝基苯酚上游产品

邻硝基苯酚下游产品

邻硝基苯酚制备

1、水解法由邻硝基氯苯经氢氧化钠溶液水解、酸化而得。将浓度为76-80g/L的氢氧化钠溶液1850-1950L加入水解锅内，再加入250kg熔融的邻硝基氯苯。当加热到140-150℃，压力约0.45MPa时，保持2.5h，然后才升温到153-155℃，压力到0.53MPa左右，继续保温3h。反应完成后，冷却到60℃。将1000L水和60L浓硫酸预先加入结晶锅中，然后压入上述的水解产物，并慢慢加入硫酸至刚果红试纸呈紫色，再加冰冷却到30℃，搅拌，抽滤，用离心机甩去母液，于是得含量为90%左右的邻硝基苯酚210kg。收率90%左右。另一种制备法是将苯酚硝化成邻硝基酚和对硝基酚的混合物，再用水蒸气蒸馏出邻硝基酚。硝化反应在15-23℃下进行，最高不得超过25℃。

2、苯酚硝化法由苯酚经硝酸硝化成邻硝基苯酚和对硝基苯酚混合物，再经水蒸气蒸馏分离而得。

邻硝基苯酚海关

[ 海关编码 ]: 2908999090

[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物（包括其磺化、硝化或亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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