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邻甲苯磺酰胺

邻甲苯磺酰胺用途

【用途一】
用作糖精、医药中间体等
【用途二】
用于制造糖精、增塑剂、粘合剂、农药、医药等产品。

邻甲苯磺酰胺名称

[ CAS 号 ]:
88-19-7

[ 中文名 ]:
邻甲苯磺胺

[ 英文名 ]:
2-Methylbenzene-1-sulfonamide

[中文别名 ]:

[英文别名 ]:

Toluene-2-sulfonamide
o-toluenesulfonamide
Toluene-2-sulphonamide
2-Methylbenzene-1-sulphonamide
MFCD00011692
o-Methylbenzenesulfonamide.
EINECS 201-808-8
2-methylbenzene-1-sulfonamide
2-Aminosulfonyltoluene
2-Sulfamoyltoluene

邻甲苯磺酰胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
330.2±35.0 °C at 760 mmHg

[ 熔点 ]:
155 °C

[ 分子式 ]:
C₇H₉NO₂S

[ 分子量 ]:
171.217

[ 闪点 ]:
153.5±25.9 °C

[ 精确质量 ]:
171.035400

[ PSA ]:
68.54000

[ LogP ]:
0.79

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
室温

邻甲苯磺酰胺MSDS

邻甲苯磺酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT4900000

CHEMICAL NAME :: o-Toluenesulfonamide

CAS REGISTRY NUMBER :: 88-19-7

BEILSTEIN REFERENCE NO. :: 1102362

LAST UPDATED :: 199712

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C7-H9-N-O2-S

MOLECULAR WEIGHT :: 171.23

WISWESSER LINE NOTATION :: ZSWR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4300 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 2500 umol/L

REFERENCE :: 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1103 No. of Facilities: 121 (estimated) No. of Industries: 4 No. of Occupations: 4 No. of Employees: 975 (estimated) No. of Female Employees: 272 (estimated)

邻甲苯磺酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H351

[ 警示性声明 ]:
P281-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
XT5075000

[ 海关编码 ]:
2935009090

邻甲苯磺酰胺合成路线

邻甲苯磺酰胺上下游产品

邻甲苯磺酰胺上游产品

邻甲苯磺酰胺下游产品

邻甲苯磺酰胺制备

由邻甲苯磺酰氯与氨水和60℃反应2h，氨化生成邻甲苯磺酰胺。将反应物冷却，过滤，得到粗品，再经活性炭脱色、酸碱精制而得成品。

邻甲苯磺酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

邻甲苯磺酰胺文献

Determination of o-toluenesulfonamide in artificial sweeteners containing saccharin.

J. Assoc. Off. Anal. Chem. 61(6) , 1528-32, (1978)

A gas-liquid chromatographic (GLC) procedure with p-toluenesulfonamide (p-TS) as an internal standard is used to determine o-toluenesulfonamide (o-TS), a major impurity in artificial sweetening substa...

Distinct reactivity of Pd(OTs)2: the intermolecular Pd(II)-catalyzed 1,2-carboamination of dienes.

J. Am. Chem. Soc. 130(31) , 10066-7, (2008)

A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ genera...

The allergens of nail polish. (I). Allergenic constituents of common nail polish and toluenesulfonamide-formaldehyde resin (TS-F-R).

Contact Dermatitis 33(3) , 157-64, (1995)

Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin laye...

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