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松果菊苷

松果菊苷用途

Echinacoside是一天然多酚化合物,具有广泛的医药活性,包括：抗氧化、抗炎症、神经保护、保肝等。

松果菊苷名称

[ CAS 号 ]:
82854-37-3

[ 中文名 ]:
松果菊苷

[ 英文名 ]:
Echinacoside

[中文别名 ]:

[英文别名 ]:

Echinacoside
UNII-I04O1DT48T

松果菊苷生物活性

[ 描述 ]:

Echinacoside是一天然多酚化合物,具有广泛的医药活性,包括：抗氧化、抗炎症、神经保护、保肝等。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

天然产物 >> 酚类

[参考文献]

[1]. Zhang D, et al. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity. Int J Biol Macromol. 2014 Sep 2;72C:243-253.

[2]. Zhu M, et al. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80.

[3]. Li F, et al. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine. 2013 Apr 15;20(6):549-57.

[4]. Li F, et al. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia. 2012 Dec;83(8):1443-50.

[5]. Li X, et al. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 2014 Aug;49(8):993-1000.

[相关活性小分子]

松果菊苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
1062.7±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₅H₄₆O₂₀

[ 分子量 ]:
786.728

[ 闪点 ]:
327.9±27.8 °C

[ 精确质量 ]:
786.258240

[ PSA ]:
324.44000

[ LogP ]:
0.14

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.698

[ 储存条件 ]:
2-8°C

松果菊苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5786500

CHEMICAL NAME :: Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-alpha-L-mannopyranosyl-(1-3)- O-(beta-D-glucopyranosyl-(1-6))-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), beta-D-

CAS REGISTRY NUMBER :: 82854-37-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C35-H40-O20

MOLECULAR WEIGHT :: 780.75

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 105,1131,1985

松果菊苷安全信息

[ 危害码 (欧洲) ]:
T+

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ5786500

松果菊苷文献

Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds.

J. Pharm. Pharmacol. 67(1) , 117-25, (2014)

Although the exact underlying mechanisms are still unknown, Plantago lanceolata L. (PL) water extracts are frequently used to stimulate wound healing and to drain abscesses. Therefore, in this experim...

Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages.

Int. J. Mol. Sci. 16 , 14655-68, (2015)

Echinacoside is a natural compound with potent reactive oxygen species (ROS)-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer cells are often under in...

Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.

Onco. Targets Ther. 8 , 3649-64, (2015)

Inhibition of the nucleotide pool sanitizing enzyme MTH1 causes extensive oxidative DNA damages and apoptosis in cancer cells and hence may be used as an anticancer strategy. As natural products have ...

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