六亚甲基二异氰酸酯

六亚甲基二异氰酸酯用途

用途一:用作生产聚氨酯涂料的原料，同时也用作干性醇酸树脂交联剂和合成纤维的原料
用途二:HDI系是脂肪族二异氰酸酯（ADI）中最重要的单体，约占ADI总需求量的60%。大部分HDI被制备成HDI缩二脲或HDI三聚体。HDI及HDI缩二脲、三聚体是生产聚氨酯涂料及聚氨酯弹性体的重要原料。以HDI 、HDI缩二脲或三聚体为原料生产的聚氨酯涂料，具有不泛黄、耐候性强等特点，广泛用于航空、汽车、建筑、木器、塑料、皮革等方面。该产品也用作干性醇酸树脂交联剂和合成纤维的原料
用途三:HDI系是脂肪族二异氰酸酯（ADI）中最重要的单体。

六亚甲基二异氰酸酯名称

[ CAS 号 ]:
822-06-0

[ 中文名 ]:
1,6-己二异氰酸酯

[ 英文名 ]:
1,6-Diisocyanatohexane

[中文别名 ]:

[英文别名 ]:

1,6-diisocyanato-hexan
1,6-diisocyanato hexane
hexane1,6-diisocyanate
1,6-hexane diisocyanate
Hexamethylene diisocyanate
EINECS 212-485-8
Hexane 1,6-diisocyanate
HMDI
desmodurn
TL 78

六亚甲基二异氰酸酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
255.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-55°C

[ 分子式 ]:
C₈H₁₂N₂O₂

[ 分子量 ]:
168.193

[ 闪点 ]:
140.0±0.0 °C

[ 精确质量 ]:
168.089874

[ PSA ]:
58.86000

[ LogP ]:
3.03

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.483

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Moisture sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, amines, acids. May react explosively with alcohols in the presence of base without a diluting solvent. Heating above 200 C may cause polymerization.

[ 水溶解性 ]:
Reacts

六亚甲基二异氰酸酯MSDS

详细MSDS(安全技术说明书)

六亚甲基二异氰酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1740000

CHEMICAL NAME :: Hexane, 1,6-diisocyanato-

CAS REGISTRY NUMBER :: 822-06-0

BEILSTEIN REFERENCE NO. :: 0956709

LAST UPDATED :: 199712

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C8-H12-N2-O2

MOLECULAR WEIGHT :: 168.22

WISWESSER LINE NOTATION :: OCN6NCO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(10),40,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 39,202,1980

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,74,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07805

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 570 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 ppm/6H/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571057

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppb/6H/13W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532755

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ppb/6H/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571057

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 ppm/6H/5D-I

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571057 *** REVIEWS *** ACGIH TLV-TWA 0.034 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.034 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.035 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.010 ppm (0.075 mg/m3);STEL 0.020 ppm JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.07 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.05 mg/m3;STEL 0.1 mg/m3 JAN 1993 OEL-POLAND:TWA 0.05 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.005 ppm (0.03 mg/m3);STEL 0.01 ppm (0.07 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.07 mg/m3);STEL 0.02 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HDI-air:10H TWA 0.035 mg/m3;CL 0.14 mg/m3/10M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4839 No. of Facilities: 238 (estimated) No. of Industries: 9 No. of Occupations: 12 No. of Employees: 4490 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4839 No. of Facilities: 1895 (estimated) No. of Industries: 21 No. of Occupations: 26 No. of Employees: 19180 (estimated) No. of Female Employees: 329 (estimated)

六亚甲基二异氰酸酯安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H317-H330-H334

[ 警示性声明 ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23;R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S26-S28-S38-S45-S28A

[ 危险品运输编码 ]:
UN 2281 6.1/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
MO1740000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2929104000

六亚甲基二异氰酸酯合成路线

详细合成路线

六亚甲基二异氰酸酯上下游产品

六亚甲基二异氰酸酯上游产品

六亚甲基二异氰酸酯下游产品

六亚甲基二异氰酸酯制备

（一）国际上HDI工业化生产方法——造盐光气化法1. 己二胺与二氧化碳或盐酸反应生成己二胺碳酸盐或盐酸盐，再经光化反应，然后经蒸馏除去溶液，经精馏得HDI。HDI与水和催化剂反应合成HDI缩二脲，然后经薄膜蒸发器蒸发，脱除残余HDI，加入溶纤剂配制成固含量75%的溶液，即得HDI缩二脲作为高档油漆用原料。每吨产品消耗已二胺（95%）约1280kg、光气4700kg。 2.利用己二酸副产物己二酸盐酸盐与光气在溶剂氯苯中反应生成六亚甲基-1,6-二异氰酸酯，再经蒸馏脱溶剂及减压分馏制得成品。（二）直接光气化法是指HDI与光气直接反应生成HDI的制备方法。反应分两步进行，第一步反应温度较低，第二步较高，故该法又称冷热两步反应法。第一步，将HDA溶解在惰性溶剂中，保持温度20-80℃（通常为40℃），导入光气，进行低温反应，发生反应（1）与反应（2），生成二氨基甲酞氯和HDA的盐酸盐。若反应温度超过80℃由于（3）进行提较快，生成的HDI会与原料HDA起化学反应，生成脲，使收率降低。但若低于20℃，需要很大的冷冻设备，不利于工业化。低温反应中，HDA与光气按氨基与光气摩尔比为（0.5-1.0）：1的速度比导入，能得到理想效果。第二步，将第一步生成的反应液升温，并保持在130-190℃，继续导入光气，进行高温反应，发生二氨基甲方酞氯脱氯化氢的反应（3），生成HDI。低于120℃时，反应（3）速度慢，对工业生产不实用；但超过200℃，容易发生聚合，生成分子量较高的物质，使HDI收率低。反应（4）进行得较慢，若反应时充分搅拌且溶液量为HDA的3倍特别在6倍以上时，可忽略不计。200℃以上，还有反应（5），200℃以下，侧难发生。待反应液变透明，反应结束。此后，用惰性气体，如氮气赶除末反应的光气和氯化氢。脱溶剂后，进行蒸馏精制，即得HDI 3.制法：

于装有搅拌器的反应瓶中，加入甲醇145mL，1,6-己二胺（2）116g（1.0mol），搅拌下控制30℃以下慢慢加入浓盐酸175mL（2.0mol）。将溶液慢慢倒入2L丙酮中，析出固体。冷却，抽滤，100mL丙酮洗涤，得1,6-己二胺盐酸盐170～187g，收率90%～99%，mp243～246℃（高于200℃时有升华）。彻底干燥。于装有搅拌器、温度计、通气导管的反应瓶中，加入上述盐酸盐94.5g（0.5mol），戊苯500mL或四氢萘500mL，剧烈搅拌下加热至180～185℃，通入无游离氯的光气，控制通入速度，约33g/h。生成的氯化氢和未反应的光气由冷凝器顶部排出并用碱水吸收。于180～185℃约通入光气8～15h（时间取决于通入光气的速度），直至不溶的盐酸盐消失。冷后过滤，减压分馏，首先回收溶剂，而后收集120～125℃/1.4kPa的馏分，得产物（1）70～80g，收率84%～95%。

六亚甲基二异氰酸酯海关

[ 海关编码 ]: 2929104000

[ 中文概述 ]:
2929104000. 六亚基甲烷二异氰酸酯. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最低关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929104000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0%

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