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4-甲基-2-氧戊酸

4-甲基-2-氧戊酸用途

4-Methyl-2-oxopentanoic acid,一种非正常代谢物,既是一种神经毒素也是一种代谢毒素。

4-甲基-2-氧戊酸名称

[ CAS 号 ]:
816-66-0

[ 中文名 ]:
4-甲基-2-氧代戊酸

[ 英文名 ]:
Ketoleucine

[中文别名 ]:

[英文别名 ]:

2-Oxo-4-methylvaleric acid
α-ketoisocaproic acid
2-Oxoisocaproic acid
2-KETOISOCAPROIC ACID
EINECS 212-435-5
4-Methyl-2-oxopentanoic acid
Pentanoic acid, 4-methyl-2-oxo-
&α;-ketoisocaproic acid
2-keto-4-Methylvaleric acid
4-Methyl-2-oxovaleric Acid

4-甲基-2-氧戊酸生物活性

[ 描述 ]:

4-Methyl-2-oxopentanoic acid,一种非正常代谢物,既是一种神经毒素也是一种代谢毒素。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Yudkoff M, et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S.

[相关活性小分子]

4-甲基-2-氧戊酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
190.5±9.0 °C at 760 mmHg

[ 熔点 ]:
8-10 °C

[ 分子式 ]:
C₆H₁₀O₃

[ 分子量 ]:
130.142

[ 闪点 ]:
83.3±15.2 °C

[ 精确质量 ]:
130.062988

[ PSA ]:
54.37000

[ LogP ]:
0.17

[ 外观性状 ]:
无色到浅黄色液体

[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C

[ 折射率 ]:
1.438

[ 储存条件 ]:
2-8°C

4-甲基-2-氧戊酸MSDS

4-甲基-2-氧戊酸安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3265 8/PG 3

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2918300090

4-甲基-2-氧戊酸合成路线

4-甲基-2-氧戊酸海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

4-甲基-2-氧戊酸文献

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.

Biochem. Pharmacol. 80(1) , 104-12, (2010)

The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective ...

Production of α-ketoisocaproate via free-whole-cell biotransformation byRhodococcus opacusDSM 43250 withl-leucine as the substrate

Enzyme Microb. Technol. 49(4) , 321-5, (2011)

This work aims to produce α-ketoisocaproate (KIC) from l-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cel...

更多文献

4-甲基-2-氧戊酸

4-甲基-2-氧戊酸用途

4-甲基-2-氧戊酸名称

4-甲基-2-氧戊酸生物活性

4-甲基-2-氧戊酸物理化学性质

4-甲基-2-氧戊酸MSDS

详细MSDS(安全技术说明书)

4-甲基-2-氧戊酸安全信息

4-甲基-2-氧戊酸合成路线

详细合成路线

4-甲基-2-氧戊酸海关

4-甲基-2-氧戊酸文献

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