美溴非林

美溴非林用途

Mebrofenin (SQ 26962) 是亚氨基二乙酸 (IDA) 的一种。Mebrofenin 可用作 Tc-99m 的放射性标记试剂盒。Tc-99m Mebrofenin 是一种诊断剂,用于肝胆显像。Tc-99m Mebrofenin 是评价肝功能的首选放射性药物。

美溴非林名称

[ CAS 号 ]:
78266-06-5

[ 中文名 ]:
美溴非林

[ 英文名 ]:
(3-bromo-2,4,6-trimethylphenylcarbamoyl)methyliminodiacetic acid

[中文别名 ]:

甲溴菲宁

[英文别名 ]:

UNII-7PV0B6ED98
MEBROFENIN
MFCD00216974
Choletec
EINECS 278-877-6

美溴非林生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

Tc-99mMebrofenin是一种99mTc标记的亚氨基二乙酸(IDA)衍生物,最初用于多种胆道疾病的诊断,最近用于肝功能评估[3]。

[参考文献]

[1]. Matthews R, et al. Tc-99m mebrofenin hepatobiliary scan in obstructive hepatobiliary disease: determining causes with early and late delayed imaging. World J Nucl Med. 2013 May;12(2):54-6.

[2]. Morandi F, et al. Transsplenic portal scintigraphy using 99mTc-mebrofenin in normal dogs. Vet Radiol Ultrasound. 2007 May-Jun;48(3):286-91.

[3]. de Graaf W, et al. Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011 Apr;54(4):738-45.

美溴非林物理化学性质

[ 密度 ]:
1.5766 (rough estimate)

[ 沸点 ]:
577.4ºC at 760 mmHg

[ 熔点 ]:
193-198ºC

[ 分子式 ]:
C₁₅H₁₉BrN₂O₅

[ 分子量 ]:
387.22600

[ 闪点 ]:
303ºC

[ 精确质量 ]:
386.04800

[ PSA ]:
106.94000

[ LogP ]:
1.85700

[ 折射率 ]:
1.6520 (estimate)

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
Soluble in dimethylsulphoxide and ethanol. Insoluble in water.

美溴非林MSDS

详细MSDS(安全技术说明书)

美溴非林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9121850

CHEMICAL NAME :: Glycine, N-(2-((3-bromo-2,4,6-trimethylphenyl)amino)-2-oxoethy l)-N-(carboxymethyl)-

CAS REGISTRY NUMBER :: 78266-06-5

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H19-Br-N2-O5

MOLECULAR WEIGHT :: 387.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 484 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CITCDE Zhonghua Heyixue Zazhi. Chinese Journal of Nuclear Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 4,214,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 226 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CITCDE Zhonghua Heyixue Zazhi. Chinese Journal of Nuclear Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 4,214,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CITCDE Zhonghua Heyixue Zazhi. Chinese Journal of Nuclear Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 4,214,1984

美溴非林安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MB9121850

[ 海关编码 ]:
2924299090

美溴非林海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%