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草铵膦

草铵膦用途

Glufosinate ammonium 是谷氨酸的膦酸类似物,是一种由植物细胞转化为 PT (L-phosphinothricin) 的除草剂。Glufosinate ammonium 具有神经毒性作用。

草铵膦名称

[ CAS 号 ]:
77182-82-2

[ 中文名 ]:
草铵膦

[ 英文名 ]:
Glufosinate ammonium

[中文别名 ]:

[英文别名 ]:

Glufosinate Ammonium
DL-Phosphinothricin, monoammonium salt
Glufosinate ammonium salt
Basta
QVYZ2PQO&1 &&(DL) Form NH4 Salt
Ammonium (DL-homoalanine-4-yl)methylphosphinate
Glufosinate-ammonium
MFCD00055562
glufosinate-ammonum
EINECS 278-636-5

草铵膦生物活性

[ 描述 ]:

Glufosinate ammonium 是谷氨酸的膦酸类似物,是一种由植物细胞转化为 PT (L-phosphinothricin) 的除草剂。Glufosinate ammonium 具有神经毒性作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

Glufosinate铵(1-100μM；12DIV)破坏分化的V-SVZ神经干细胞(NSC)中的细胞-细胞粘附[2]。Glufosinate铵(1-100μM；12DIV)在100μM显著降低Celsr2基因表达[2]。草甘膦酸铵损害室管膜细胞合成纤毛的能力[2]。RT-PCR【2】细胞系：室管膜细胞浓度：1,3,10,100μM孵育时间：12DIV(NSCs至室管膜细胞时间点)结果：100μM时Celsr2基因表达明显降低。

[体内研究]

谷胱甘肽铵(10-250毫克/公斤；灌胃；每日；妊娠6~15天)表明在Wistar大鼠中给予50或250毫克/千克组的母体毒性〔3〕。在雄性和雌性大鼠的半衰期不到4小时的情况下,血液中的Glufosinate铵(经口插管)被清除[3]。

[参考文献]

[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945.

[2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163.

[3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.

草铵膦物理化学性质

[ 沸点 ]:
519.1ºC at 760 mmHg

[ 熔点 ]:
210°C

[ 分子式 ]:
C₅H₁₅N₂O₄P

[ 分子量 ]:
215.18800

[ 闪点 ]:
100 °C

[ 精确质量 ]:
215.10300

[ PSA ]:
116.09000

[ LogP ]:
0.24480

[ 外观性状 ]:
结晶固体

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：完全溶解；水溶解度：1,370,000 mg/l 22 °C；不溶：甲苯,丙酮,乙醇

草铵膦MSDS

详细MSDS(安全技术说明书)

草铵膦毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7713600

CHEMICAL NAME :: Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt

CAS REGISTRY NUMBER :: 77182-82-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C5-H11-N-O4-P.H4-N

MOLECULAR WEIGHT :: 198.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1600 uL/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 7,47,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,17,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C154,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A810,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 416 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13978 mg/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

草铵膦安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312 + H332-H360Fd-H373

[ 警示性声明 ]:
P201-P260-P280-P301 + P312 + P330-P308 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
53-45

[ 危险品运输编码 ]:
2588

[ RTECS号 ]:
EK7713600

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2931901917

草铵膦合成路线

详细合成路线

草铵膦上下游产品

草铵膦上游产品

草铵膦下游产品

草铵膦制备

将O，O-二乙基甲基膦酸与二溴乙烷反应，于80℃加热2h得BrCH2CH2P(O)(OC2H5)CH3,再与(C2H5O2C)2CNa(NHCOCH3)于85℃反应制得(C2H5O2C)2C(NHCOCH3)CH2CH2P(O)(OC2H5)CH3，后者与盐酸回流，所得化合物与28%氢氧化铵在60～70℃反应8h制得草铵膦。
此外，草铵膦合成还有高压催化合成法、低温定向合成法、采用斯特累克尔反应和密切尔加成法等。

草铵膦海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

草铵膦文献

A review of methods for the analysis of orphan and difficult pesticides: glyphosate, glufosinate, quaternary ammonium and phenoxy acid herbicides, and dithiocarbamate and phthalimide fungicides.

J. AOAC Int. 97(4) , 965-77, (2014)

This article reviews the chromatography/MS methodologies for analysis of pesticide residues of orphan and difficult chemical classes in a variety of sample matrixes including water, urine, blood, and ...

Repression of flowering under a noninductive photoperiod by the HDA9-AGL19-FT module in Arabidopsis.

New Phytol. 206(1) , 281-94, (2015)

Posttranslational acetylation of histones is reversibly regulated by histone deacetylases (HDACs). Despite the evident significance of HDACs in Arabidopsis development, the biological roles and underl...

Role of glutamate receptors and nitric oxide on the effects of glufosinate ammonium, an organophosphate pesticide, on in vivo dopamine release in rat striatum.

Toxicology 311(3) , 154-61, (2013)

The purpose of the present work was to assess the possible role of glutamatergic receptors and nitric oxide (NO) production on effects of glufosinate ammonium (GLA), an organophosphate pesticide struc...

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草铵膦