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五氟苯酚

五氟苯酚用途

五氟苯酚是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

五氟苯酚名称

[ CAS 号 ]:
771-61-9

[ 中文名 ]:
五氟苯酚

[ 英文名 ]:
Pentafluorophenol

[中文别名 ]:

[英文别名 ]:

Pentaflurophenol
PENTAFLUORPHENOL
SM6680000 [RTECS]
QR BF CF DF EF FF
HOPFP
PERFLUOROPHENOL
2,3,4,5,6-Pentafluorophenol
pentafluoro-pheno
PFP-OH
Pentafluorophenol

五氟苯酚生物活性

[ 描述 ]:

五氟苯酚是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

五氟苯酚用于制备五氟苯酯,用于多肽合成和硫化聚合物。它还用于肽偶联和杂环酸衍生物。参与制备五氟苯甲酸酯,作为胺类和氨基酸的配剂。

五氟苯酚物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
146.3±35.0 °C at 760 mmHg

[ 熔点 ]:
34-36 °C(lit.)

[ 分子式 ]:
C₆HF₅O

[ 分子量 ]:
184.06

[ 闪点 ]:
72.2±0.0 °C

[ 精确质量 ]:
183.994751

[ PSA ]:
20.23000

[ LogP ]:
3.05

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
3.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.429

[ 储存条件 ]:
Store in dark!

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, bases, acid chlorides, acid anhydrides.

[ 水溶解性 ]:
soluble

五氟苯酚MSDS

五氟苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM6680000

CHEMICAL NAME :: Phenol, pentafluoro-

CAS REGISTRY NUMBER :: 771-61-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H-F5-O

MOLECULAR WEIGHT :: 184.07

WISWESSER LINE NOTATION :: QR BF CF DF EF FF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 322 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 283 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4108 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 90 (estimated) No. of Female Employees: 68 (estimated)

五氟苯酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
C:Corrosive;Xi:Irritant;

[ 风险声明 (欧洲) ]:
R20/21/22;R34;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37/39-S36/37-S24/25-S23-S53

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
SM6680000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29081000

五氟苯酚合成路线

五氟苯酚上下游产品

五氟苯酚上游产品

五氟苯酚下游产品

五氟苯酚制备

由氢氧化钠和全氟代苯亲核取代反应而得到。

五氟苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

五氟苯酚文献

Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.

Angew. Chem. Int. Ed. Engl. 45(16) , 2609-15, (2006)

Atmospheric pressure chemical ionization of fluorinated phenols in atmospheric pressure chemical ionization mass spectrometry, tandem mass spectrometry, and ion mobility spectrometry.

J. Am. Soc. Mass Spectrom. 10(11) , 1157-65, (1999)

Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) for fluorinated phenols (C6H5-xFxOH Where x = 0-5) in nitrogen with Cl- as the reagent ion yielded product ions of M Cl- through ...

Development and validation of a RP-HPLC method for the determination of gentamicin sulfate and its related substances in a pharmaceutical cream using a short pentafluorophenyl column and a charged aerosol detector.

J. Pharm. Biomed. Anal. 51(3) , 521-31, (2010)

Gentamicin sulfate is a potent broad spectrum aminoglycoside antibiotic which is used as an active pharmaceutical ingredient (API) against both Gram-positive and Gram-negative bacteria. A reversed-pha...

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