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beta-雌二醇 17-半琥珀酸酯

beta-雌二醇 17-半琥珀酸酯用途

β-Estradiol 17-hemisuccinate 是雌二醇 estradiol (HY-B0141) 的合成衍生物。

beta-雌二醇 17-半琥珀酸酯名称

[ CAS 号 ]:
7698-93-3

[ 中文名 ]:
beta-雌二醇 17-半琥珀酸酯

[ 英文名 ]:
beta-Estradiol 17-hemisuccinate

[中文别名 ]:

[英文别名 ]:

17beta-Estradiol hemisuccinate
Eutocol (TN)
17BETA-ESTRADIOL 17-HEMISUCCINATE
Estradiol-17-hemisuccinate
beta-Estradiol 17-hemisuccinate

beta-雌二醇 17-半琥珀酸酯生物活性

[ 描述 ]:

β-Estradiol 17-hemisuccinate 是雌二醇 estradiol (HY-B0141) 的合成衍生物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Gaikwad NW. Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue. Anal Chem. 2013 May 21;85(10):4951-60.

beta-雌二醇 17-半琥珀酸酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
570.1±50.0 °C at 760 mmHg

[ 熔点 ]:
162-164°C (lit.)

[ 分子式 ]:
C₂₂H₂₈O₅

[ 分子量 ]:
372.455

[ 闪点 ]:
198.7±23.6 °C

[ 精确质量 ]:
372.193665

[ PSA ]:
83.83000

[ LogP ]:
4.64

[ 外观性状 ]:
米白色至浅米色固体

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
2-8°C，惰性气体

beta-雌二醇 17-半琥珀酸酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332-H351

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22-40

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

beta-雌二醇 17-半琥珀酸酯合成路线

详细合成路线

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beta-雌二醇 17-半琥珀酸酯文献

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.

J. Neuroimmunol. , (2008)

Estrogen has been shown to attenuate the inflammatory response following injury or lipopolysaccharide treatment in several organ systems. Estrogen's actions are transduced through two estrogen recepto...

Steroid-bovine serum albumin conjugates: molecular characterization and their interaction with androgen and estrogen receptors.

J. Steroid Biochem. 24(5) , 1017-31, (1986)

Conjugates of testosterone-3-carboxymethyloxime (T-3-CMO), testosterone-17-hemisuccinate (T-17-HS), 17 beta-estradiol-6-carboxymethyloxime (E-6-CMO), or 17 beta-estradiol-17-hemisuccinate (E-17-HS) an...

Prevention of bridge binding in immunoassays: a general estradiol tracer structure.

J. Steroid Biochem. 32(2) , 251-7, (1989)

Iodinated estradiol tracers were synthesized with three different bridges connecting the radiolabelled moiety to the steroid core: Hemisuccinate, carboxymethyloxime and amide. Taking these iodinated t...

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