二硫代磷酸O,O'-二甲酯

二硫代磷酸O,O'-二甲酯用途

【用途1】
用作农药中间体，主要用于制备乐果、马拉硫磷等有机磷农药
【用途2】
O，O-二甲基二硫代磷酸酯简称甲基硫化物，是重要的有机磷农药中间体，可直接合成杀虫剂乐果、马拉硫磷、亚胺硫磷、稻丰散，除草剂莎稗磷，杀菌剂克菌壮等，还可通过氯化得到另一有机磷中间体O，O-二甲基硫代磷酰氯。

二硫代磷酸O,O'-二甲酯名称

[ CAS 号 ]:
756-80-9

[ 中文名 ]:
二甲基二硫代磷酸酯

[ 英文名 ]:
Dimethylphosphorodithioate

[英文别名 ]:

O,O-dimethyl phosphorodithioic acid
dithiophosphorus acid O,O-dimethyl ester
Dimethylphosphorodithioate
EINECS 212-053-9
O,O-Dimethyl phosphorodithioate
Dimethyl phosphodithionate
dithiophosphoric acid-O.O-dimethyl ester
O,O-Dimethyldithiophosphate
O,O-dimethyldithiophosphoric acid
Dimethyldithiophosphoric acid

二硫代磷酸O,O'-二甲酯物理化学性质

[ 密度 ]:
1.29

[ 沸点 ]:
65ºC

[ 分子式 ]:
C₂H₇O₂PS₂

[ 分子量 ]:
158.18000

[ 闪点 ]:
71.2ºC

[ 精确质量 ]:
157.96300

[ PSA ]:
99.16000

[ LogP ]:
2.08410

[ 外观性状 ]:
液体;Colorless to Light yellow to Red clear liquid

[ 折射率 ]:
1.535

[ 储存条件 ]:
-20°C

二硫代磷酸O,O'-二甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TE0525000

CHEMICAL NAME :: Phosphorodithioic acid, O,O-dimethyl ester

CAS REGISTRY NUMBER :: 756-80-9

BEILSTEIN REFERENCE NO. :: 0635993

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H7-O2-P-S2

MOLECULAR WEIGHT :: 158.18

WISWESSER LINE NOTATION :: SHPS&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 28,599,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68500 ug/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

REFERENCE :: AITDAQ Archiwum Immunologii i Terapii Doswiadczalnej. (Warsaw, Poland) V.1-9, 1953-61. For publisher information, see AITEAT. Volume(issue)/page/year: 6,333,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 161 mg/m3/6H

SEX/DURATION :: male 11 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0385-0547

二硫代磷酸O,O'-二甲酯合成路线

详细合成路线

二硫代磷酸O,O'-二甲酯上下游产品

二硫代磷酸O,O'-二甲酯上游产品

二硫代磷酸O,O'-二甲酯下游产品

二硫代磷酸O,O'-二甲酯制备

由五硫化二磷与甲醇进行酯化反应制得。将一定量的硫化物与五硫化二磷按质量比约0.7:1加入反应罐中，搅拌同时按一定摩尔比滴加甲醇，控制滴加温度在40~45℃，约2h加完，再于50~55℃继续搅拌反应约2h，冷却至35℃出料即得成品，收率75%以上。反应生成的硫化氢导入吸收塔内用碱液吸收。