叔丁胺

叔丁胺用途

【用途一】
橡胶工业用于制造橡胶促进剂，制药工业用于制造利福平。农药工业用于制造杀虫剂、杀菌剂。染料工业用于制造染料着色剂。有机工业用作有机合成中间体。分析化学中用作化学试剂。
【用途二】
用于合成橡胶促进剂、农药、医药、表面活性剂等
【用途三】
叔丁胺是制备丁醚脲的中间体，还可用作药物、橡胶促进剂和染料着色剂的中间剂。
【用途四】
有机合成原料，用以合成医药、橡胶硫化促进剂、杀虫剂、杀菌剂和染料着色剂，也可用作溶剂。可用于生产利福平、N-特丁基-2-苯并噻唑次磺酰胺、特丁氨基乙醇甲基丙烯酸酯等。N-叔丁基-2-苯并噻唑次磺酰胺（促进剂NS）在美国的生产量和消费量很大，占噻唑类硫化用化学品（包括硫化剂和硫化促进剂）总量的40%，促进剂NS是由促进剂M或DM与叔丁胺经氧化缩合制得的。由于国内叔丁胺生产未形成规模，影响了仲进剂NS的工业化生产。
【用途五】
有机合成原料，用以合成医药、橡胶硫化促进剂、杀虫剂、杀菌剂和染料着色剂，也可用作溶剂。

叔丁胺名称

[ CAS 号 ]:
75-64-9

[ 中文名 ]:
叔丁胺

[ 英文名 ]:
tert-Butylamine

[中文别名 ]:

[英文别名 ]:

T-BUTYLAMINE
Butylamine,tert
MFCD00008050
tert-Butylamine
erbumine
tert-C4H9NH2
1-amino-1,1-dimethylethane
butylamine,tertiary
2-methyl-2-propaneamine
1,1-dimethyl-ethylamine

叔丁胺物理化学性质

[ 密度 ]:
0.696 g/mL at 25 °C(lit.)

[ 沸点 ]:
46 °C(lit.)

[ 熔点 ]:
-67 °C

[ 分子式 ]:
C₄H₁₁N

[ 分子量 ]:
73.13680

[ 闪点 ]:
−36.4 °F

[ 精确质量 ]:
73.08910

[ PSA ]:
26.02000

[ LogP ]:
1.44390

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.5 (vs air)

[ 蒸汽压 ]:
5.7 psi ( 20 °C)

[ 折射率 ]:
n20/D 1.377(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents. Highly flammable.

[ 水溶解性 ]:
MISCIBLE

叔丁胺MSDS

详细MSDS(安全技术说明书)

叔丁胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO3330000

CHEMICAL NAME :: tert-Butylamine

CAS REGISTRY NUMBER :: 75-64-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H11-N

MOLECULAR WEIGHT :: 73.16

WISWESSER LINE NOTATION :: ZX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 40 mg/m3/8H-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 48,26,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534846

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - dyspnea Blood - hemorrhage

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570798

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 378 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570521

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2010 mg/m3/6H/13W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538640 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14444 No. of Facilities: 219 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1268 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14444 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

叔丁胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H314-H331-H412

[ 警示性声明 ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R20;R25;R35

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 3286 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
EO3330000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
29211980

叔丁胺合成路线

详细合成路线

叔丁胺上下游产品

叔丁胺上游产品

叔丁胺下游产品

叔丁胺制备

1.以叔丁醇和尿素为原料在硫酸中缩合、水解，得叔丁基脲，再用40%的氢氧化钠中和，经水洗、滤干，加液碱、乙二醇混合后加热，收集40-60℃蒸馏物，然后加固碱干燥，常压分馏，切取44-47℃馏分得叔丁胺成品。原料消耗定额：叔丁醇（98%）2400kg/t、尿素2400kg/t、浓硫酸（98%）460kg/t。2.异丁烯-氢氰酸法制叔丁胺首先将异丁烯与氢氰酸反应，生成叔丁胺硫酸盐，然后与氨中和，制得叔丁胺，同时副产硫酸氢铵3.根据有关资料报道，叔丁胺除上述制法外，还有下述几种方法：以三甲基乙酰胺为原料用溴素和氢氧化钾还原法；叔丁基氯与乙醇、氨共热法等。

2.叔丁胺是由叔丁醇经缩合、水解而得。
(1)缩合
叔丁醇与尿素缩合得叔丁脲。

在干燥的反应锅内加入硫酸，搅拌冷却，在15～25℃缓缓加入尿素，维持20～25℃再加入叔丁醇，加毕，搅拌0.5h，放置过夜。将反应物放入冰水中，加20％氢氧化钠溶液中和至pH=3～4，冷至15～17℃过滤，用冰水洗涤，滤饼加水煮沸溶解，趁热过滤，滤液冷至0～5℃析出结晶，过滤干燥得叔丁脲。
(2)水解

将氢氧化钠溶液、叔丁脲、乙二醇加入反应锅，加热回流4h。将反应物进行蒸馏，收集40～90℃馏分，得粗叔丁胺。加少量固体氢氧化钠干燥过夜，粗馏，收集43～52℃馏分，得精制的叔丁胺。
美国罗姆-哈斯公司采用异丁烯为原料，与氢氰酸反应后用氨中和得产品。

叔丁胺海关

[ 海关编码 ]: 29211980

叔丁胺文献

Multilayered Thin Films from Boronic Acid-Functional Poly(amido amine)s.

Pharm. Res. 32(9) , 3066-86, (2015)

To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and ...

Ion chromatography of amylamine and tert.-butylamine in pharmaceuticals.

J. Chromatogr. A. 739(1-2) , 343-9, (1996)

Ion chromatographic (IC) methods have been developed for the assay of amylamine in BMS-181 866-02 and tert.-butylamine (TBA) in BMS-188 494-04. BMS-181 866-02 is the penultimate intermediate in the sy...

[Hygienic standard for tert-butylamine in water].

Gig. Sanit. (12) , 70-1, (1985)

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叔丁胺