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氯烯

氯烯用途

盐酸氯ricromene(氯ricromine)是一种血小板聚集抑制剂。盐酸氯米罗明可以抑制人和实验性血栓形成中的血小板聚集[1]。

氯烯名称

[ CAS 号 ]:
74697-28-2

[ 中文名 ]:
氯烯

[ 英文名 ]:
Cloricromenehydrochloride

[英文别名 ]:

AD6
Cloricromen hydrochloride
Proendotel (TN)
Cloricromen hydrohloride

氯烯生物活性

[ 描述 ]:

盐酸氯ricromene(氯ricromine)是一种血小板聚集抑制剂。盐酸氯米罗明可以抑制人和实验性血栓形成中的血小板聚集[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. G Orefice, et al. No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease. J Int Med Res. 1994 Sep-Oct;22(5):287-91.

氯烯物理化学性质

[ 沸点 ]:
538ºC at 760 mmHg

[ 熔点 ]:
221-222.3ºC

[ 分子式 ]:
C₂₀H₂₇Cl₂NO₅

[ 分子量 ]:
432.33800

[ 闪点 ]:
279.2ºC

[ 精确质量 ]:
431.12700

[ PSA ]:
68.98000

[ LogP ]:
4.38300

氯烯MSDS

详细MSDS(安全技术说明书)

氯烯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
AF8970000

氯烯文献

Cloricromene in endotoxemia: role of NF-kappaB.

Naunyn Schmiedebergs Arch. Pharmacol. 370(2) , 140-5, (2004)

In this study we investigated, for the first time in vivo, the effect of cloricromene, a cumarine derivative, on NF-kappaB activation in endotoxin-treated rats. Endotoxemia was induced in male rats by...

Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.

Am. J. Physiol. 268(4 Pt 2) , H1412-7, (1995)

Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis fac...

Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.

AAPS PharmSciTech 7(1) , E27, (2006)

The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle su...

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氯烯