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4-溴苯乙胺

4-溴苯乙胺用途

ZH8651 是 TAAR1 的激动剂,可同时激活 Gs 和 Gq 信号通路。ZH8651 可用于研究精神分裂症。

4-溴苯乙胺名称

[ CAS 号 ]:
73918-56-6

[ 中文名 ]:
4-溴苯乙胺

[ 英文名 ]:
4-Bromophenethylamine

[中文别名 ]:

[英文别名 ]:

2-(4-bromophenyl)ethan-1-amine
Benzeneethanamine, 4-bromo-
EINECS 277-636-2
2-(4-Bromophenyl)ethanamine
4-Bromophenethylamine
MFCD00008189
2-(4-Bromophenyl)ethylamine

4-溴苯乙胺生物活性

[ 描述 ]:

ZH8651 是 TAAR1 的激动剂,可同时激活 Gs 和 Gq 信号通路。ZH8651 可用于研究精神分裂症。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Shang P, et al. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24.

4-溴苯乙胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
271.3±0.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₀BrN

[ 分子量 ]:
200.076

[ 闪点 ]:
113.1±20.4 °C

[ 精确质量 ]:
198.999649

[ PSA ]:
26.02000

[ LogP ]:
2.23

[ 外观性状 ]:
透明黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
室温

4-溴苯乙胺MSDS

4-溴苯乙胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8.0

[ 海关编码 ]:
2921499090

4-溴苯乙胺合成路线

4-溴苯乙胺上下游产品

4-溴苯乙胺上游产品

4-溴苯乙胺下游产品

4-溴苯乙胺海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-溴苯乙胺文献

A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha.

J. Org. Chem. 71 , 5781, (2006)

We have developed two simple and high yielding one-pot syntheses of alkyl aminoaryl sulfides containing a series of four-steps: in situ protection of the free amine by reaction with a Grignard reagent...

Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA.

Anal. Bioanal. Chem 397 , 665-75, (2010)

Based on the template of a recently introduced derivatization reagent for aldehydes, 4-(2-(trimethylammonio)ethoxy)benzeneaminium dibromide (4-APC), a new derivatization agent was designed with additi...

Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel. Kim JH, et al.

Tetrahedron 54(26) , 7395-7400, (1998)

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