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p, p’-DDE标准溶液

p, p’-DDE标准溶液用途

p,p'-DDE (4,4'-DDE) 是持久性 DDT 的主要代谢产物,是一种有效的雄激素受体拮抗剂,IC50 为5 μM,Ki 为 3.5 μM。

p, p’-DDE标准溶液名称

[ CAS 号 ]:
72-55-9

[ 中文名 ]:
2-乙基噻吩

[ 英文名 ]:
p,p'-DDE

[中文别名 ]:

[英文别名 ]:

Benzene, 1,1'-(dichloroethenylidene)bis[4-chloro-
DDE
p,p'-DDE
1,1-bis(4-chlorophenyl)-2,2-dichloroethylene
2,2-Bis(4-chlorophenyl)-1,1-dichloroethylene
dichlorodiphenyldichloroethylene
para,para'-DDE
EINECS 200-784-6
DDE, p,p'-
MFCD00003284

p, p’-DDE标准溶液生物活性

[ 描述 ]:

p,p'-DDE (4,4'-DDE) 是持久性 DDT 的主要代谢产物,是一种有效的雄激素受体拮抗剂,IC50 为5 μM,Ki 为 3.5 μM。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 雄激素受体

[参考文献]

[1]. Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.

p, p’-DDE标准溶液物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
383.1±37.0 °C at 760 mmHg

[ 熔点 ]:
88-90 °C(lit.)

[ 分子式 ]:
C₁₄H₈Cl₄

[ 分子量 ]:
318.025

[ 闪点 ]:
183.7±23.9 °C

[ 精确质量 ]:
315.938019

[ LogP ]:
6.37

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.622

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable, but light-sensitive. Incompatible with strong bases, strong oxidizing agents.

p, p’-DDE标准溶液MSDS

p, p’-DDE标准溶液毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV9450000

CHEMICAL NAME :: Ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 72-55-9

BEILSTEIN REFERENCE NO. :: 1913355

LAST UPDATED :: 199710

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C14-H8-Cl4

MOLECULAR WEIGHT :: 318.02

WISWESSER LINE NOTATION :: GYGUYR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg/6W-C

TOXIC EFFECTS :: Liver - changes in liver weight Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 586 mg/kg/28D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: 76160 ug/kg/8W-C

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic Liver - changes in liver weight Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9700 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 36 gm/kg/86W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 57 gm/kg/68W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 41 gm/kg/97W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 81 gm/kg/97W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3500 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,137,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,83,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 48,141,1973

p, p’-DDE标准溶液安全信息

[ 符号 ]:

GHS02, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370-H411

[ 警示性声明 ]:
P210-P260-P273-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R33

[ 安全声明 (欧洲) ]:
36/37-60-61-45-16-7-62

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
KV9450000

[ 海关编码 ]:
2903999090

p, p’-DDE标准溶液合成路线

p, p’-DDE标准溶液海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

p, p’-DDE标准溶液文献

Risk assessment for children exposed to DDT residues in various milk types from the Greek market.

Food Chem. Toxicol. 75 , 156-65, (2015)

The occurrence of residues of DDT and its metabolites was monitored in 196 cow milk samples of various pasteurized commercial types collected from the Greek market. Residue levels were determined by G...

Three decades (1983-2010) of contaminant trends in East Greenland polar bears (Ursus maritimus). Part 1: legacy organochlorine contaminants.

Environ. Int. 59 , 485-93, (2013)

Legacy organochlorine contaminants were determined in adipose tissues from 294 polar bears (Ursus maritimus) sampled in East Greenland in 23 of the 28years between 1983 and 2010. Of 19 major legacy co...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

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