依地芬

依地芬用途

依地福新是一种合成烷基-赖氨磷脂，具有抗肿瘤活性。该化合物诱导多种癌细胞的凋亡。乙二胺嘧啶在细胞膜中积累，在细胞膜中改变脂质成分并诱导脂质筏和 Fas/CD95 死亡受体的共簇。

依地芬名称

[ CAS 号 ]:
70641-51-9

[ 中文名 ]:
依地福新

[ 英文名 ]:
Edelfosine

[英文别名 ]:

alkyllysophospholipid
Alizarine Yellow R
Alizarol Orange R
Edelfosine
UNII:1Y6SNA8L5S
alizarin yellow R
Kenachrome Orange
mordant orange 1
Pnbas
Chrome Orange MR

依地芬物理化学性质

[ 分子式 ]:
C₂₇H₅₈NO₆P

[ 分子量 ]:
523.726

[ 精确质量 ]:
523.400146

[ PSA ]:
86.86000

[ LogP ]:
4.65

[ 外观性状 ]:
蜡质固体

[ 储存条件 ]:
20°C

依地芬MSDS

依地芬毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YK0718000

CHEMICAL NAME :: 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide, (+-)-

CAS REGISTRY NUMBER :: 70641-51-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H58-N-O6-P

MOLECULAR WEIGHT :: 523.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mg/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5538,1983

依地芬安全信息

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

依地芬合成路线

依地芬上下游产品

依地芬上游产品

依地芬下游产品

依地芬文献

Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.

Tissue Eng. Part A 21(5-6) , 948-59, (2015)

Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bon...

Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage.

PLoS ONE 9(10) , e111059, (2014)

Mesenchymal stem cells (MSCs) are viewed as safe, readily available and promising adult stem cells, which are currently used in several clinical trials. Additionally, their soluble-factor secretion an...

Knock-down of p300 decreases the proliferation and odontogenic differentiation potentiality of HDPCs.

Int. Endod. J. 48 , 976-85, (2015)

To investigate the role of p300 in the regulation of proliferation and odontogenic differentiation of human dental pulp cells (HDPCs).The recombinant lentiviral vector pshRNA-copGFP was used to knock-...

更多文献

依地芬