阿克罗宁
阿克罗宁名称
[ CAS 号 ]:
7008-42-6
[ 中文名 ]:
阿克罗宁
[ 英文名 ]:
7H-Pyrano[2,3-c]acridin-7-one,3,12-dihydro-6-methoxy-3,3,12-trimethyl-
[中文别名 ]:
[英文别名 ]:
- Acronina [INN-Spanish]
- Acromycine
- ACRONYCINE
- Acronine
- Acroninum [INN-Latin]
- 4-27-00-03622
阿克罗宁物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
489.8±45.0 °C at 760 mmHg
[ 熔点 ]:
175-176ºC
[ 分子式 ]:
C20H19NO3
[ 分子量 ]:
323.386
[ 闪点 ]:
250.0±28.7 °C
[ 精确质量 ]:
323.152130
[ PSA ]:
40.46000
[ LogP ]:
2.99
[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C
[ 折射率 ]:
1.612
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放
阿克罗宁毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ0330000
- CHEMICAL NAME :
- 7H-Pyrano(2,3-c)acridin-7-one, 3,12-dihydro-6-methoxy-3,3,12-trimethyl-
- CAS REGISTRY NUMBER :
- 7008-42-6
- BEILSTEIN REFERENCE NO. :
- 0312954
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C20-H19-N-O3
- MOLECULAR WEIGHT :
- 321.40
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 522 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 613 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1170 mg/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Musculoskeletal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 585 mg/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 530 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Fibroblast
- DOSE/DURATION :
- 10 mg/L/24H
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1549,1977
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