苍耳烷氢化物

苍耳烷氢化物用途

氢化黄原素是寡核苷酸合成的一个重要原料,别名3-氨基-1,2,4-二噻唑-5-硫酮,分子式C2H2N2S3,黄色晶体,常用于有机合成,是硫代反义寡核苷酸固相合成的硫代步骤中常用的硫代试剂之一。硫代反义寡核苷酸是用硫原子将反义寡核苷酸磷酸骨架上的非成键氧原子取代而形成的一类反义寡核苷酸类似物,由于寡核苷酸硫代修饰以后,克服了反义寡核苷酸在血清中被酶降解的特性,因此在治疗癌症以及抑制基因的表达方面有着重要的作用。在硫代寡核苷酸的固相合成中,一旦载体上的寡核苷酸与亚磷酰胺核苷偶联以后,就需要对新偶联上的核苷酸硫代氧化,硫代反应的收率影响硫代反义寡核苷酸的产品纯度,硫代的不完全会引入氧代的杂质,因此硫代试剂的质量对硫代反义寡核苷酸的合成以及终产品的含量有着重要的影响。

苍耳烷氢化物名称

[ CAS 号 ]:
6846-35-1

[ 中文名 ]:
3-氨基-1,2,4-二噻唑-5-硫酮

[ 英文名 ]:
Xanthane Hydride

[中文别名 ]:

[英文别名 ]:

5-Amino-3H-1,2,4-dithiazole-3-thione
Xanthane Hydride
MFCD00051660
3-imino-3H-1,2,4-dithiazole-5-thiol
3H-1,2,4-Dithiazole-3-thione, 5-amino-
5-amino-1,2,4-dithiazole-3-thione
3-Amino-1,2,4-dthiazole-5-thione
3H-1,2,4-Dithiazole-5-thiol, 3-imino-
EINECS 229-933-3

苍耳烷氢化物物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
282.0±23.0 °C at 760 mmHg

[ 熔点 ]:
201-203°C

[ 分子式 ]:
C₂H₂N₂S₃

[ 分子量 ]:
150.246

[ 闪点 ]:
124.4±22.6 °C

[ 精确质量 ]:
149.938004

[ PSA ]:
127.48000

[ LogP ]:
-0.09

[ 外观性状 ]:
固体;Light yellow to Brown powder to crystal

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.986

[ 储存条件 ]:
室温，干燥

苍耳烷氢化物MSDS

详细MSDS(安全技术说明书)

苍耳烷氢化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JO6500000

CHEMICAL NAME :: 1,2,4-Dithiazolidine-3-thione, 5-imino-

CAS REGISTRY NUMBER :: 6846-35-1

BEILSTEIN REFERENCE NO. :: 0112403

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C2-H2-N2-S3

MOLECULAR WEIGHT :: 150.24

WISWESSER LINE NOTATION :: T5MYSSYJ BUS EUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3050 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(4),90,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(4),90,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00229

苍耳烷氢化物安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
JO6500000

[ 海关编码 ]:
2934100090

苍耳烷氢化物合成路线

详细合成路线

苍耳烷氢化物上下游产品

苍耳烷氢化物上游产品

苍耳烷氢化物下游产品

苍耳烷氢化物海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%