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酮康唑侧链

酮康唑侧链用途

酮康唑的中间体。

酮康唑侧链名称

[ CAS 号 ]:
67914-60-7

[ 中文名 ]:
1-乙酰基-4-(4-羟基苯基)哌嗪

[ 英文名 ]:
1-Acetyl-4-(4-hydroxyphenyl)-piperazine

[中文别名 ]:

[英文别名 ]:

1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanone
ethanone, 1-4-(4-hydroxyphenyl)-1-piperazinyl-
1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone
EINECS 267-744-8
1-4-(4-hydroxyphenyl)piperazin-1-ylethanone
MFCD00044905
Ethanone, 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-
1-Acetyl-4-(4-hydroxyphenyl)-piperazine
1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanon

酮康唑侧链物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
456.5±40.0 °C at 760 mmHg

[ 熔点 ]:
180-185 °C(lit.)

[ 分子式 ]:
C₁₂H₁₆N₂O₂

[ 分子量 ]:
220.268

[ 闪点 ]:
229.9±27.3 °C

[ 精确质量 ]:
220.121185

[ PSA ]:
43.78000

[ LogP ]:
0.19

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
4.3 g/L (20 ºC)

酮康唑侧链MSDS

酮康唑侧链安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933599090

酮康唑侧链合成路线

酮康唑侧链上下游产品

酮康唑侧链上游产品

酮康唑侧链下游产品

酮康唑侧链制备

可用六水哌嗪先与对硝基氯苯缩合，生成1-（4-硝基苯基）哌嗪，然后与乙酸酐反应得到1-乙酰基-4-（4-硝基苯基）哌嗪，将后者经硝基还原、重氮化、水解后制得该品。

酮康唑侧链海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

酮康唑侧链文献

General approach for electrochemical detection of persistent pharmaceutical micropollutants: Application to acetaminophen.

Biosens. Bioelectron. 72 , 205-10, (2015)

We propose in this work a general and versatile methodology for electrochemical monitoring of persistent pharmaceutical micropollutants. The system presented is based on an electroactive and electropo...

New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl) piperazine [J]. Zheng, CZ, et al.

Huaxue Shiji 10 , 27, (2010)

Design of new potent and selective secretory phospholipase A₂ inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives. Meddad-Belhabich N, et al.

Bioorg. Med. Chem. 18(10) , 3588-3600, (2010)

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