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柚皮素

柚皮素用途

(±)-Naringenin 是一种天然类黄酮。(±)-Naringenin 通过激活肌细胞中 BKCa通道对内皮剥脱血管起血管舒张作用。

柚皮素名称

[ CAS 号 ]:
67604-48-2

[ 中文名 ]:
柚皮素

[ 英文名 ]:
(±)-Naringenin

[中文别名 ]:

[英文别名 ]:

Naringenin
(+)-(2R)-naringenin
(R)-naringenin
4',5,7-Trihydroxyflavanone
(+)-Naringenin
MFCD00006844
5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one
Naringenine
EINECS 266-769-1

柚皮素生物活性

[ 描述 ]:

(±)-Naringenin 是一种天然类黄酮。(±)-Naringenin 通过激活肌细胞中 BKCa通道对内皮剥脱血管起血管舒张作用。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Saponara S, et al. (+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 2006 Dec;149(8):1013-21.

柚皮素物理化学性质

[ 密度 ]:
1.485g/cm3

[ 沸点 ]:
577.5ºC at 760mmHg

[ 熔点 ]:
247-250 °C(lit.)

[ 分子式 ]:
C₁₅H₁₂O₅

[ 分子量 ]:
272.25300

[ 精确质量 ]:
272.06800

[ PSA ]:
83.83000

[ LogP ]:
2.13750

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 储存条件 ]:
0-6°C

柚皮素MSDS

详细MSDS(安全技术说明书)

柚皮素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ2981530

柚皮素文献

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.

Br. J. Nutr. 113(5) , 770-82, (2015)

Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin ...

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

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柚皮素