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GBR 12935二盐酸盐

GBR 12935二盐酸盐用途

GBR 12935双盐酸盐是多巴胺再吸收抑制剂。

GBR 12935二盐酸盐名称

[ CAS 号 ]:
67469-81-2

[ 中文名 ]:
1-(2-二苯基甲氧基乙基)-4-(3-苯基丙基)哌嗪双盐酸盐

[ 英文名 ]:
GBR 12935 dihydrochloride

[英文别名 ]:

GBR 12935 dihydrochloride
GBR 12935 (dihydrochloride)

GBR 12935二盐酸盐生物活性

[ 描述 ]:

GBR 12935双盐酸盐是多巴胺再吸收抑制剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 多巴胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9.

[2]. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44.

[3]. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9.

[相关活性小分子]

GBR 12935二盐酸盐物理化学性质

[ 沸点 ]:
564ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₃₆Cl₂N₂O

[ 分子量 ]:
487.504

[ 闪点 ]:
294.9ºC

[ 精确质量 ]:
486.220459

[ PSA ]:
15.71000

[ LogP ]:
6.52280

[ 外观性状 ]:
white solid

[ 储存条件 ]:
-20℃

GBR 12935二盐酸盐MSDS

GBR 12935二盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

GBR 12935二盐酸盐合成路线

GBR 12935二盐酸盐文献

Plasma membrane monoamine transporters: structure, regulation and function.

Nat. Rev. Neurosci. 4 , 13-25, (2003)

Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.

J. Pharmacol. Exp. Ther. 268 , 1462-1475, (1994)

The present study addressed the hypothesis that there exist multiple sites/states associated with the dopamine (DA) transporter ligands. The authors used [3H](1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylp...

[3H]GBR-12935 binding to cytochrome P450 in the human brain.

J. Neurochem. 62 , 342-348, (1994)

The presence of multiple [3H]GBR-12935 binding sites in the human brain has been revealed in several recent studies. One site represents the dopamine uptake site. In rat brain it was demonstrated that...

更多文献

GBR 12935二盐酸盐

GBR 12935二盐酸盐用途

GBR 12935二盐酸盐名称

GBR 12935二盐酸盐生物活性

GBR 12935二盐酸盐物理化学性质

GBR 12935二盐酸盐MSDS

详细MSDS(安全技术说明书)

GBR 12935二盐酸盐安全信息

GBR 12935二盐酸盐合成路线

详细合成路线

GBR 12935二盐酸盐文献

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