托扎啉酮

托扎啉酮用途

Thozalinone也被称为5-苯基-2-二甲基氨基-2-恶唑啉-4-酮,是一种具有抗四苯那嗪抑郁活性的兴奋剂。Thozalinone具有独特的特性,区别于拟交感神经胺[1]。

托扎啉酮名称

[ CAS 号 ]:
655-05-0

[ 中文名 ]:
托扎啉酮

[ 英文名 ]:
Thozalinone

[中文别名 ]:

2-(二甲基氨基)-5-苯基-2-恶唑啉-4-酮

[英文别名 ]:

2-Dimethylamino-5-phenyl-4-oxazolinon-(4)
Tozalinona [INN-Spanish]
2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl
5-Phenyl-2-dimethylamino-2-oxazolin-4-on
2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one
2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin
2-Dimethylamino-4-oxo-5-phenyl-oxazolin
Tozalinonum [INN-Latin]
Stimsen
2-dimethylamino-5-phenyl-oxazol-4-one

托扎啉酮生物活性

[ 描述 ]:

Thozalinone也被称为5-苯基-2-二甲基氨基-2-恶唑啉-4-酮,是一种具有抗四苯那嗪抑郁活性的兴奋剂。Thozalinone具有独特的特性,区别于拟交感神经胺[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78.

托扎啉酮物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
294.8ºC at 760 mmHg

[ 熔点 ]:
134.5ºC

[ 分子式 ]:
C₁₁H₁₂N₂O₂

[ 分子量 ]:
204.23

[ 闪点 ]:
132.1ºC

[ 精确质量 ]:
204.09000

[ PSA ]:
41.90000

[ LogP ]:
0.63770

[ 折射率 ]:
1.584

[ 储存条件 ]:
2-8°C

托扎啉酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5775000

CHEMICAL NAME :: 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-

CAS REGISTRY NUMBER :: 655-05-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T5NV DO CHJ CR& EN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3000 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

托扎啉酮安全信息

[ 海关编码 ]:
2934999090

托扎啉酮合成路线

详细合成路线

托扎啉酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%