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盐酸普莫卡因

盐酸普莫卡因用途

Pramocaine盐酸盐是一种局部麻醉剂, 用作止痒剂。

盐酸普莫卡因名称

[ CAS 号 ]:
637-58-1

[ 中文名 ]:
盐酸普莫卡因

[ 英文名 ]:
Pramoxine HCl

[中文别名 ]:

普莫卡因

[英文别名 ]:

proctofoam
EINECS 211-293-1
Pramoxine hydrochloride
Tronothane hydrochloride
pramoxine HCl
MFCD00054323
Proxazocain Hydrochloride
Pramocaine (hydrochloride)

盐酸普莫卡因生物活性

[ 描述 ]:

Pramocaine盐酸盐是一种局部麻醉剂, 用作止痒剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[相关活性小分子]

盐酸普莫卡因物理化学性质

[ 沸点 ]:
427ºC at 760 mmHg

[ 熔点 ]:
181-183ºC

[ 分子式 ]:
C₁₇H₂₈ClNO₃

[ 分子量 ]:
329.862

[ 闪点 ]:
123.5ºC

[ 精确质量 ]:
329.175781

[ PSA ]:
30.93000

[ LogP ]:
3.70650

[ 外观性状 ]:
白色或灰白色结晶粉末

[ 储存条件 ]:
室温

盐酸普莫卡因MSDS

详细MSDS(安全技术说明书)

盐酸普莫卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD8750000

CHEMICAL NAME :: Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride

CAS REGISTRY NUMBER :: 637-58-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H27-N-O3.Cl-H

MOLECULAR WEIGHT :: 329.91

WISWESSER LINE NOTATION :: T6N DOTJ A3OR DO4 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,454,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80493 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80493 No. of Facilities: 98 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 16892 (estimated) No. of Female Employees: 15582 (estimated)

盐酸普莫卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QD8750000

[ 海关编码 ]:
2934999090

盐酸普莫卡因海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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