N-(1H-苯并咪唑-2-基)氨基甲酸乙酯

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯用途

洛本唑是一种强效的驱虫药。洛本达唑抑制肠贾第鞭毛虫菌株[1]。

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯名称

[ CAS 号 ]:
6306-71-4

[ 中文名 ]:
N-(1H-苯并咪唑-2-基)氨基甲酸乙酯

[ 英文名 ]:
N-(1H-Benzimidazol-2-yl)carbamic acid ethyl ester

[中文别名 ]:

洛苯达唑

[英文别名 ]:

Ethyl 2-benzimidazolecarbamate
Lobendazole
Ethyl 2-benzimidazolylcarbamate
Ethyl 1H-benzimidazol-2-ylcarbamate
ethyl benzimidazole-2-carbamate
2-Carboethoxyaminobenzimidazole

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯生物活性

[ 描述 ]:

洛本唑是一种强效的驱虫药。洛本达唑抑制肠贾第鞭毛虫菌株[1]。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Jaime Pérez-Villanueva, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110.

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯物理化学性质

[ 密度 ]:
1.358

[ 分子式 ]:
C₁₀H₁₁N₃O₂

[ 分子量 ]:
205.21

[ 精确质量 ]:
205.08500

[ PSA ]:
67.01000

[ LogP ]:
2.20430

[ 折射率 ]:
1.682

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EY8590000

CHEMICAL NAME :: Carbamic acid, (2-benzimidazolyl)-, ethyl ester

CAS REGISTRY NUMBER :: 6306-71-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N3-O2

MOLECULAR WEIGHT :: 205.24

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04389 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 82400 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 21,87,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 164 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - physical

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 21,87,1990

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯安全信息

[ 海关编码 ]:
2933990090

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯上下游产品

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯上游产品

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯下游产品

N-(1H-苯并咪唑-2-基)氨基甲酸乙酯海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%