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乙基丙二酸

乙基丙二酸用途

Ethylmalonic acid 是一种非致癌性的潜在有毒物质,与神经性厌食和甲氧基脱羧酶缺乏症有关。

乙基丙二酸名称

[ CAS 号 ]:
601-75-2

[ 中文名 ]:
乙基丙二酸

[ 英文名 ]:
Ethylmalonic acid

[中文别名 ]:

[英文别名 ]:

MFCD00002668
EINECS 210-007-2
2-ethylpropanedioic acid
Ethylmalonic acid

乙基丙二酸生物活性

[ 描述 ]:

Ethylmalonic acid 是一种非致癌性的潜在有毒物质,与神经性厌食和甲氧基脱羧酶缺乏症有关。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Gregersen N, et al. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91.

[2]. Yano S, et al. A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy. Eur J Pediatr. 1997 May;156(5):382-3.

[相关活性小分子]

乙基丙二酸物理化学性质

[ 密度 ]:
1.311 g/cm3

[ 沸点 ]:
322.2ºC at 760 mmHg

[ 熔点 ]:
109-114 ºC

[ 分子式 ]:
C₅H₈O₄

[ 分子量 ]:
132.11500

[ 闪点 ]:
162.9ºC

[ 精确质量 ]:
132.04200

[ PSA ]:
74.60000

[ LogP ]:
0.18180

[ 外观性状 ]:
白色至淡的粉红色结晶粉末

[ 储存条件 ]:
室温，干燥

乙基丙二酸MSDS

详细MSDS(安全技术说明书)

乙基丙二酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2917190090

乙基丙二酸制备

三、生产方法简述

以丁酸乙酯与草酸乙酯进行缩合制取。

乙基丙二酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

乙基丙二酸文献

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J. Chromatogr. A. 562(1-2) , 125-38, (1991)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease...

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