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N-(2,6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸

用途

利多卡因是一种亚氨基二乙酸(IDA)衍生物。利非宁可用于肝胆研究[1]。

名称

[ CAS 号 ]:
59160-29-1

[ 中文名 ]:
N-(2,6-二甲基乙酰苯胺)亚氨基二乙酸

[ 英文名 ]:
Lidofenin

[中文别名 ]:

[英文别名 ]:

EINECS 261-636-4
MFCD00038399

生物活性

[ 描述 ]:

利多卡因是一种亚氨基二乙酸(IDA)衍生物。利非宁可用于肝胆研究[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Chiotellis E, Sawas-Dimopoulou C, Koutoulidis C, Constantinides M. 99MTc-HIDA, a gallbladder imaging agent: experimental aspects. Eur J Nucl Med. 1978;3(1):41-6

物理化学性质

[ 密度 ]:
1.352 g/cm3

[ 沸点 ]:
546.3ºC at 760 mmHg

[ 熔点 ]:
210ºC (dec.)(lit.)

[ 分子式 ]:
C₁₄H₁₈N₂O₅

[ 分子量 ]:
294.30

[ 闪点 ]:
284.2ºC

[ 精确质量 ]:
294.12200

[ PSA ]:
106.94000

[ LogP ]:
0.78610

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.5110 (estimate)

[ 储存条件 ]:
室温

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH1846000

CHEMICAL NAME :: Acetic acid, 2,2'-(N-(2,6-dimethylphenylcarbamoylmethyl)imino)di-

CAS REGISTRY NUMBER :: 59160-29-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H18-N2-O5

MOLECULAR WEIGHT :: 294.34

WISWESSER LINE NOTATION :: QV1N1VQ1VMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - change in rate Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 6,1331,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJNMD9 European Journal of Nuclear Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1976- Volume(issue)/page/year: 3,41,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNMEAQ Journal of Nuclear Medicine. (Samuel N. Turiel & Associates, Inc., 4 30 North Michigan Avenue, Chicago, IL, DElaware 7-3511) V.1- 1960- Volume(issue)/page/year: 18,997,1977

安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ WGK德国 ]:
3

[ RTECS号 ]:
AH1846000

[ 海关编码 ]:
2924299090

合成路线

详细合成路线

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海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%