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盐酸苯肼

盐酸苯肼用途

【用途一】
用作医药、农药及染料中间体
【用途二】
用作医药、农药中间体及染料中间体。
【用途三】
醛、酮和糖的特殊试剂。主要用于合成农药、医药、染料及合成其它有机物。

盐酸苯肼名称

[ CAS 号 ]:
59-88-1

[ 中文名 ]:
盐酸苯肼

[ 英文名 ]:
Phenylhydrazine hydrochloride

[中文别名 ]:

[英文别名 ]:

Phenylhydrazine hydrochloride
Phenylhydrazine hydrochloride (1:1)
EINECS 200-444-7
MFCD00012924
Hydrazine, phenyl-, hydrochloride (1:1)
Phenylhydrazinium Chloride

盐酸苯肼物理化学性质

[ 密度 ]:
1.125g/cm3

[ 沸点 ]:
243ºC at 760 mmHg

[ 熔点 ]:
250-254 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₉ClN₂

[ 分子量 ]:
144.602

[ 闪点 ]:
115.4ºC

[ 精确质量 ]:
144.045425

[ PSA ]:
38.05000

[ LogP ]:
2.54750

[ 外观性状 ]:
白色至棕色结晶粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with most common metals.

[ 水溶解性 ]:
50 g/L (20 ºC)

盐酸苯肼MSDS

盐酸苯肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV9000000

CHEMICAL NAME :: Hydrazine, phenyl-, hydrochloride

CAS REGISTRY NUMBER :: 59-88-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C6-H8-N2.Cl-H

MOLECULAR WEIGHT :: 144.62

WISWESSER LINE NOTATION :: ZMR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 161 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - corrosive (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg/42W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 464 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg/58W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 928 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Rodent - mouse Liver

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,204,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81928 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81928 No. of Facilities: 63 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 645 (estimated) No. of Female Employees: 445 (estimated)

盐酸苯肼安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H317-H319-H341-H350-H372-H410

[ 警示性声明 ]:
P201-P261-P280-P301 + P310 + P330-P308 + P313-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R36/38;R43;R45;R48/23/24/25;R50;R68

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MV9000000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29280090

盐酸苯肼合成路线

盐酸苯肼上下游产品

盐酸苯肼上游产品

盐酸苯肼下游产品

盐酸苯肼海关

[ 海关编码 ]: 29280090

盐酸苯肼文献

Characterization of a Functional Role of the Bradyrhizobium japonicum Isocitrate Lyase in Desiccation Tolerance.

Int. J. Mol. Sci. 16 , 16695-709, (2015)

Bradyrhizobium japonicum is a nitrogen-fixing symbiont of soybean. In previous studies, transcriptomic profiling of B. japonicum USDA110, grown under various environmental conditions, revealed the hig...

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

PLoS ONE 10 , e0142655, (2015)

Erythroid enucleation is critical for terminal differentiation of red blood cells, and involves extrusion of the nucleus by orthochromatic erythroblasts to produce reticulocytes. Due to the difficulty...

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Gastroenterology 146(5) , 1325-38, (2014)

The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogeno...

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