酸性金黄G

酸性金黄G用途

Acid Yellow 36 (Metanil Yellow),一种偶氮染料和 pH 指示剂,Acid Yellow 36 的 pH 值从 1.2 到 2.3 时,颜色从红色变为变为黄色。Acid Yellow 36 用于皮革、造纸和纺织工业。Acid Yellow 36 是 P-450 特异性同工酶和胞浆酶的双功能诱导剂。

酸性金黄G名称

[ CAS 号 ]:
587-98-4

[ 中文名 ]:
丫啶黄

[ 英文名 ]:
Acid Yellow 36

[中文别名 ]:

[英文别名 ]:

Victoriagelb O
Acid Yellow 36
Ext. D & C Yellow No.1
Monoazo
Metanil Yellow C
Metanil Yellow E
Acid Metanil Yellow
TROPAEOLIN G
Metanilgelb extra
Kiton Yellow MS

酸性金黄G生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

酸性黄36(间苯胺黄)作为微粒体P-450和胞质谷胱甘肽-S-转移酶(GST)和醌还原酶(QR)的诱导剂,可能涉及胞质Ah受体[3]。

[参考文献]

[1]. Sharma UK, et al. Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats. Food Chem Toxicol. 2019;126:34-40.

[2]. Nakano N, et al. Development of a monitoring system for vinyl chloride gas in air by using an HCl monitoring tape and pyrolyzer. Talanta. 1996;43(3):459-463.

[3]. Ramchandani S, et al. Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters. J Appl Toxicol. 1997;17(1):85-91.

酸性金黄G物理化学性质

[ 分子式 ]:
C₁₈H₁₄N₃NaO₃S

[ 分子量 ]:
375.377

[ 精确质量 ]:
375.065369

[ PSA ]:
102.33000

[ LogP ]:
5.90350

[ 外观性状 ]:
橙色至黄色粉末

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
水溶性：可溶；可溶于：醇；微溶：苯,乙醚；极微溶：丙酮

酸性金黄GMSDS

详细MSDS(安全技术说明书)

酸性金黄G毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB7329500

CHEMICAL NAME :: Benzenesulfonic acid, 3-((4-(phenylamino)phenyl)azo)-, monosodium salt

CAS REGISTRY NUMBER :: 587-98-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C18-H14-N3-O3-S.Na

MOLECULAR WEIGHT :: 375.40

WISWESSER LINE NOTATION :: WSO&R CNUNR DMR &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/90D-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Autonomic Nervous System - sympathomimetic Behavioral - alteration of operant conditioning

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6450 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg/3D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 gm/kg/26W-C

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 162 gm/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 31,299,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1438 No. of Facilities: 455 (estimated) No. of Industries: 10 No. of Occupations: 22 No. of Employees: 5070 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1438 No. of Facilities: 2370 (estimated) No. of Industries: 32 No. of Occupations: 33 No. of Employees: 52679 (estimated) No. of Female Employees: 18156 (estimated)

酸性金黄G安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S22-S24/25-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DB7329500

酸性金黄G上下游产品

酸性金黄G上游产品

酸性金黄G下游产品

酸性金黄G制备

1.以间氨基苯磺酸和二苯胺为原料，将间氨基苯磺酸重氮化，与二苯胺偶合得产物。经盐析、过滤、干燥、粉碎得成品。。

酸性金黄G文献

Modification of Luna's technique for staining eosinophils in the hamster cheek pouch.

Biotech. Histochem. 83(3) , 147-51, (2008)

The cheek pouch is an anatomical peculiarity of hamsters, widely used as an experimental model for oral cancer, and characterization of its normal cell populations and the changes they undergo in path...

[Simultaneous determination of 15 industrial synthetic dyes in condiment by solid phase extraction-high performance liquid chromatography].

Se Pu 29(2) , 162-7, (2011)

A new method was established for the determination of 15 industrial synthetic dyes in condiment by solid phase extraction-high performance liquid chromatography (SPE-HPLC). The samples were extracted ...

Effect of metanil yellow, orange II and their blend on hepatic xenobiotic metabolizing enzymes in rats.

Food Chem. Toxicol. 32(6) , 559-63, (1994)

The effects of Metanil yellow, Orange II and their blend on hepatic xenobiotic metabolizing enzymes were compared. Parenteral administration of Metanil yellow and Orange II to rats at a dose of 80 mg/...

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