依利醋铵
依利醋铵用途
乙酸椭圆体(NSC 264137)是一种DNA插入剂,对L1210细胞具有高度细胞毒性,并与L1210细胞的核酸共价结合。醋酸Elliptium可用于癌症研究,尤其是转移性乳腺癌[1][2]。
依利醋铵名称
[ CAS 号 ]:
58337-35-2
[ 中文名 ]:
依利醋铵
[ 英文名 ]:
H9M2E
[英文别名 ]:
- ELLIPTINIUM ACETATE
- Ellipticine acetomethylate
- 9-hydroxy-2-methylellipticinium acetate
- elliptinium
- Elliptinii acetas [INN-Latin]
- EINECS 261-216-0
- Acetato de eliptinio [INN-Spanish]
- Acetate d'elliptinium [INN-French]
- Celiptium
- 9-hydroxy-N-2-methylellipticinium acetate
依利醋铵生物活性
[ 描述 ]:
乙酸椭圆体(NSC 264137)是一种DNA插入剂,对L1210细胞具有高度细胞毒性,并与L1210细胞的核酸共价结合。醋酸Elliptium可用于癌症研究,尤其是转移性乳腺癌[1][2]。
[ 相关类别 ]:
[ 靶点 ]
Nucleic acids[1][2].
[体外研究]
Elliptium(0.35µM;1 h)(9-OH-NME3)显示出与L1210细胞的核酸高度稳定的共价键合[1]。细胞活力测定[1]细胞系:L1 210细胞浓度:0.35µM培养时间:1小时结果:显示出与DNA和RNA高度稳定的共价键。当细胞在40h期间继续复制时,结合没有逆转。
依利醋铵物理化学性质
[ 分子式 ]:
C20H20N2O3
[ 分子量 ]:
336.38400
[ 精确质量 ]:
336.14700
[ PSA ]:
80.03000
[ LogP ]:
2.37740
依利醋铵毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU8875500
- CHEMICAL NAME :
- 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl-, acetate
- CAS REGISTRY NUMBER :
- 58337-35-2
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C18-H17-N2-O.C2-H3-O2
- MOLECULAR WEIGHT :
- 336.42
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg/8W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,281,1987
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