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西替普塔林

西替普塔林用途

Setiptiline(Org-8282)为5羟色胺受体拮抗剂。

西替普塔林名称

[ CAS 号 ]:
57262-94-9

[ 中文名 ]:
司普替林

[ 英文名 ]:
Setiptiline

[中文别名 ]:

[英文别名 ]:

ORG 8282
Setiptilina [Spanish]
EINECS 260-653-4
MO 8282
Setiptilinum [Latin]
Teciptiline

西替普塔林生物活性

[ 描述 ]:

Setiptiline(Org-8282)为5羟色胺受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[参考文献]

[1]. Yamada K, Furukawa T. [Behavioral effects of a new antidepressant, setiptiline]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):31-9.

[2]. Kamimura M, Aoba A, Yamaguchi N et al. The effect of age on plasma level of setiptiline maleate in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):1015-26.

[3]. Kuniyoshi M, Nakamura J, Miura C, Inanaga K. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46.

[4]. Niho T, Ito C, Shibutani Y, Hashizume H, Yamaguchi K. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88(4):309-20.

[相关活性小分子]

西替普塔林物理化学性质

[ 密度 ]:
1.15

[ 沸点 ]:
421.7ºC at 760mmHg

[ 分子式 ]:
C₁₉H₁₉N

[ 分子量 ]:
261.36100

[ 闪点 ]:
185.5ºC

[ 精确质量 ]:
261.15200

[ PSA ]:
3.24000

[ LogP ]:
3.77500

[ 折射率 ]:
1.656

[ 储存条件 ]:
2-8℃

西替普塔林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO7578000

CAS REGISTRY NUMBER :: 57262-94-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H19-N

MOLECULAR WEIGHT :: 261.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 554 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4447437

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 423 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #81-65825

西替普塔林制备

化合物(I)在多聚磷酸中加热环合而得。