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1-Boc-哌嗪

1-Boc-哌嗪用途

N-Boc-piperazine 是一种 PROTAC linker,属于 Alkyl/ether 类。可用于合成 PROTAC PD-1/PD-L1 degrader-1 (HY-131183)。

1-Boc-哌嗪名称

[ CAS 号 ]:
57260-71-6

[ 中文名 ]:
1-Boc-哌嗪

[ 英文名 ]:
N-Boc-piperazine

[中文别名 ]:

[英文别名 ]:

piperazine-1-carboxylic acid tert-butyl ester
BOC-PIPERAZINE
2-Methyl-2-propanyl 1-piperazinecarboxylate
1-Boc piperzine
t-Butyl 1-piperazincarboxylate
tert-butyl piperazine-1-carboxylate
1,1-Dimethylethyl 1-piperazinecarboxylate
1-BOC-Piperazine
PIBOC
MFCD00075265

1-Boc-哌嗪生物活性

[ 描述 ]:

N-Boc-piperazine 是一种 PROTAC linker,属于 Alkyl/ether 类。可用于合成 PROTAC PD-1/PD-L1 degrader-1 (HY-131183)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[体外研究]

protac包含两个不同的配体,通过一个连接体连接；一个是E3泛素连接酶的配体,另一个是靶蛋白的配体。PROTACs利用细胞内泛素蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

1-Boc-哌嗪物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
258.0±15.0 °C at 760 mmHg

[ 熔点 ]:
47-49ºC

[ 分子式 ]:
C₉H₁₈N₂O₂

[ 分子量 ]:
186.251

[ 闪点 ]:
109.8±20.4 °C

[ 精确质量 ]:
186.136826

[ PSA ]:
41.57000

[ LogP ]:
0.55

[ 外观性状 ]:
白色或淡黄色晶体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.467

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
可溶于：甲醇

1-Boc-哌嗪MSDS

1-Boc-哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1-Boc-哌嗪合成路线

1-Boc-哌嗪上下游产品

1-Boc-哌嗪上游产品

1-Boc-哌嗪下游产品

1-Boc-哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-Boc-哌嗪文献

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.

J. Enzyme Inhib. Med. Chem. , (2013)

A series of new 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones have been synthesized and evaluated for dual D2 and 5-HT1A receptor binding affinities. The synthesized ligands are struc...

Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Bioorg. Med. Chem. Lett. 14 , 2857-2862, (2004)

In this study, we report the design, synthesis and structure-activity relationships of novel indazole derivatives as DNA gyrase inhibitors with Gram-positive antibacterial activity. Our results show t...

Molecular iodine-catalyzed facile procedure for N-Boc protection of amines.

J. Org. Chem. 71 , 8283, (2006)

An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular i...

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