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盐酸苄替米特

盐酸苄替米特用途

Benzetimide盐酸盐是一种乙酰胆碱受体拮抗剂, 有较强的中枢和外周抗胆碱能作用, 治疗抗精神病药物引起的巴金森氏综合症。

盐酸苄替米特名称

[ CAS 号 ]:
5633-14-7

[ 中文名 ]:
盐酸苄替米特

[ 英文名 ]:
Benzetimide hydrochloride

[中文别名 ]:

[英文别名 ]:

Dioxatrine
Spasmentral
R 4929
Benzetimide HCl
EINECS 227-072-8
McN-JR4929
BENZETIMIDE HYDROCHLORIDE
Benzetimide (hydrochloride)

盐酸苄替米特生物活性

[ 描述 ]:

Benzetimide盐酸盐是一种乙酰胆碱受体拮抗剂, 有较强的中枢和外周抗胆碱能作用, 治疗抗精神病药物引起的巴金森氏综合症。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[相关活性小分子]

盐酸苄替米特物理化学性质

[ 沸点 ]:
543.9ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₂₇ClN₂O₂

[ 分子量 ]:
398.926

[ 闪点 ]:
282.7ºC

[ 精确质量 ]:
398.176117

[ PSA ]:
52.90000

[ LogP ]:
4.28900

[ 储存条件 ]:
2-8℃

盐酸苄替米特MSDS

详细MSDS(安全技术说明书)

盐酸苄替米特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4030000

CHEMICAL NAME :: Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, hydrochloride

CAS REGISTRY NUMBER :: 5633-14-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H26-N2-O2.Cl-H

MOLECULAR WEIGHT :: 398.97

WISWESSER LINE NOTATION :: T6VMVTJ DR& D- DT6NTJ A1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37600 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,283,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

盐酸苄替米特安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)