R-文拉法辛

R-文拉法辛用途

(+)-Warfarin is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the

R-文拉法辛名称

[ CAS 号 ]:
5543-58-8

[ 中文名 ]:
R-文拉法辛

[ 英文名 ]:
(S)-(−)-Warfarin

[英文别名 ]:

Warfarin
EINECS 226-908-9
(R)-Warfarin
R-(+)-Warfarin
(-)-Warfarin
(S)-Warfarin
MFCD00272376
(R)-(+)-WARFARIN
(+)-Warfarin
(S)-(-)-Warfarin

R-文拉法辛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
515.2±50.0 °C at 760 mmHg

[ 熔点 ]:
≥170ºC

[ 分子式 ]:
C₁₉H₁₆O₄

[ 分子量 ]:
308.328

[ 闪点 ]:
188.8±23.6 °C

[ 精确质量 ]:
308.104858

[ PSA ]:
67.51000

[ LogP ]:
3.42

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
-20°C，密闭，干燥

R-文拉法辛安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360D-H372-H412

[ 警示性声明 ]:
P201-P273-P308 + P313

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
61-48/25-52/53

[ 安全声明 (欧洲) ]:
53-45-61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

R-文拉法辛文献

Hologram QSAR model for the prediction of human oral bioavailability.

Bioorg. Med. Chem. 15 , 7738-45, (2007)

A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical devel...

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.

J. Thromb. Haemost. 8(12) , 2708-17, (2010)

Warfarin, an antagonist of vitamin K, is an oral coumarin anticoagulant widely used to control and prevent thromboembolic disorders. Warfarin is clinically available as a racemic mixture of R- and S-w...

Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples.

Proteomics. Clin. Appl. 4(10-11) , 808-15, (2010)

warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It interferes with the vitamin K cycle to achieve anti-coagulating effects. Warfarin has two enantiomers, S(-) and R...

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