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醋甲唑胺

醋甲唑胺用途

Methazolamide是碳酸酐酶抑制剂,可作用于青光眼。

醋甲唑胺名称

[ CAS 号 ]:
554-57-4

[ 中文名 ]:
醋甲唑胺

[ 英文名 ]:
Methazolamide

[中文别名 ]:

醋酸卡泊芬净

[英文别名 ]:

methazolamide
Methazolamide [BAN:INN:JAN]
Methazolamide (JAN/USP)
EINECS 209-066-7
Metazolamide [DCIT]
NEPTAZANE
4-27-00-08221 (Beilstein Handbook Reference)
MFCD00083416

醋甲唑胺生物活性

[ 描述 ]:

Methazolamide是碳酸酐酶抑制剂,可作用于青光眼。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶

研究领域 >> 其他

[参考文献]

[1]. Casini, A., et al., Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV. Bioorg Med Chem Lett, 2003. 13(5): p. 841-5.

[2]. Kiwull-Schone, H.F., et al., Methazolamide does not impair respiratory work performance in anesthetized rabbits. Am J Physiol Regul Integr Comp Physiol, 2009. 297(3): p. R648-54.

[3]. Skorobohach, B.J., D.A. Ward, and D.V. Hendrix, Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Am J Vet Res, 2003. 64(2): p. 183-7.

[相关活性小分子]

醋甲唑胺物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
402.0±28.0 °C at 760 mmHg

[ 熔点 ]:
208ºC (dec.)

[ 分子式 ]:
C₅H₈N₄O₃S₂

[ 分子量 ]:
236.272

[ 闪点 ]:
196.9±24.0 °C

[ 精确质量 ]:
236.003784

[ PSA ]:
144.03000

[ LogP ]:
0.13

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.737

[ 储存条件 ]:
2-8°C

醋甲唑胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC6350000

CHEMICAL NAME :: Acetamide, N-(4-methyl-2-sulfamoyl-delta(sup 2)-1,3,4-thiadiazolin-5-ylidene)-

CAS REGISTRY NUMBER :: 554-57-4

BEILSTEIN REFERENCE NO. :: 0232387

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H8-N4-O3-S2

MOLECULAR WEIGHT :: 236.29

WISWESSER LINE NOTATION :: T5NNYSJ B CUNV1 ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2420 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,351,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,819,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7129 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)

醋甲唑胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H351

[ 警示性声明 ]:
P261-P280-P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R40

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC6350000

[ 海关编码 ]:
2935009090

醋甲唑胺上下游产品

醋甲唑胺上游产品

醋甲唑胺下游产品

醋甲唑胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

醋甲唑胺文献

Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD.

Psychopharmacology 232 , 3763-72, (2015)

Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine t...

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