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丁硫克百威溶液

丁硫克百威溶液用途

Carbosulfan强效抑制CYP3A4, 适度抑制CYP1A1/2和CYP2C19。

丁硫克百威溶液名称

[ CAS 号 ]:
55285-14-8

[ 中文名 ]:
丁硫克百威

[ 英文名 ]:
Carbosulfan

[中文别名 ]:

[英文别名 ]:

marshall
Carbosulfan
Sheriff
MARSHAL
AMITAGE
DBSC
EINECS 259-565-9
MFCD00143930
Posse
Versal

丁硫克百威溶液生物活性

[ 描述 ]:

Carbosulfan强效抑制CYP3A4, 适度抑制CYP1A1/2和CYP2C19。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 感染

[参考文献]

[1]. Abass K, et al. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact. 2010 May 14;185(3):163-173.

[相关活性小分子]

丁硫克百威溶液物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
462.5±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₂N₂O₃S

[ 分子量 ]:
380.545

[ 闪点 ]:
233.5±31.5 °C

[ 精确质量 ]:
380.213348

[ PSA ]:
67.31000

[ LogP ]:
6.05

[ 外观性状 ]:
黏的棕色液体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

丁硫克百威溶液MSDS

详细MSDS(安全技术说明书)

丁硫克百威溶液毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EZ3815000

CHEMICAL NAME :: Carbamic acid, ((dibutylamino)thio)methyl-, 2,2-dimethyl-2,3-dihydro-7-benzofuranyl ester

CAS REGISTRY NUMBER :: 55285-14-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C20-H32-N2-O3-S

MOLECULAR WEIGHT :: 380.60

WISWESSER LINE NOTATION :: T56 BOT&J C1 C1 HOVN1&SN4&4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1530 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 8100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 29600 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,111,1995

丁硫克百威溶液安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317-H330-H410

[ 警示性声明 ]:
P260-P273-P280-P284-P301 + P310-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/25;R43;R50/53

[ 安全声明 (欧洲) ]:
S24-S37-S38-S45-S60-S61

[ 危险品运输编码 ]:
UN 2810

[ RTECS号 ]:
EZ3815000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

丁硫克百威溶液上下游产品

丁硫克百威溶液上游产品

丁硫克百威溶液下游产品

丁硫克百威溶液制备

制备方法一
二正丁氨基氯化硫的制备加入二正丁胺、石油醚（60～90℃），搅拌冷却至0℃，然后缓慢滴加二氯化二硫，维持0～10℃，加毕后保温反应2h，二正丁胺、二氯化二硫、硫酰氯的配比为1:0.6:0.55(mol)，收率88%。
丁硫克百威的合成二正丁氨基氯化硫与克百威反应，配比为1:1，反应过程加适量碱液，反应温度10～20℃。反应时间2h。反应毕加水搅拌10min，过滤，滤潭为未反应克百威，可回用。滤液分层，油层减压脱溶，收率90%。
制备方法二
中间体羟基化合物的合成方法见克百威。也有文献报道，由环己酮和异丁醛出发，经过叉醇醛缩合、氯化反应、芳环化反应、水解反应、闭环反应五步合成。其特点是由非芳香族化合物合成，是一种选择性很高的合成路线。

中间体羟基化合物的合成方法见克百威。也有文献报道，由环己酮和异丁醛出发，经过叉醇醛缩合、氯化反应、芳环化反应、水解反应、闭环反应五步合成。其特点是由非芳香族化合物合成，是一种选择性很高的合成路线。

丁硫克百威溶液文献

Nature of N-S bond cleavage of 2,3-dihydro-2,2-dimethyl-7-benzofuranyl (di-n-butylaminosulfenyl) (methyl)carbamate.

J. Environ. Sci. Health B 15(1) , 1-23, (1980)

The cleavage of the N-S bond in 2,3-dihydro-2,2-dimethyl-7-benzofuranyl (di-n-butylaminosulfenyl) (methyl)carbamate was examined in different buffer solutions (hydrolysis), in buffer solution containi...

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