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颠茄提取物

颠茄提取物用途

【用途一】
竞争性非选择性蕈毒性乙酰胆碱拮抗剂。常在实验动物上进行莨菪碱诱导健忘症实验。

颠茄提取物名称

[ CAS 号 ]:
55-16-3

[ 中文名 ]:
(-)-盐酸东莨菪碱

[ 英文名 ]:
(−)-Scopolamine hydrochloride

[中文别名 ]:

[英文别名 ]:

scopolamine HCl
UNII-Q2P66EIP1F
Scopolamine hydrochloride
hyoscine hydrochloride
SCOPINE TROPATE
chlorhydratedescopolamine
EINECS 200-225-6
(-)-Scopolamine hydrochloride
er),hcl
SCOPINE TROPATE HYDROCHLORIDE

颠茄提取物物理化学性质

[ 沸点 ]:
460.3ºC at 760mmHg

[ 分子式 ]:
C₁₇H₂₂ClNO₄

[ 分子量 ]:
339.814

[ 闪点 ]:
232.2ºC

[ 精确质量 ]:
339.123749

[ PSA ]:
62.30000

[ LogP ]:
1.65800

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
H2O: 50 mg/mL

颠茄提取物MSDS

详细MSDS(安全技术说明书)

颠茄提取物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1634501

CHEMICAL NAME :: Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4)) non-7-yl ester, hydrochloride, (7(S)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))-

CAS REGISTRY NUMBER :: 55-16-3

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H21-N-O4.Cl-H

MOLECULAR WEIGHT :: 339.85

WISWESSER LINE NOTATION :: T C356 A AN DOTJ A1 HOVYR&1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 88,713,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 29,39,1972

颠茄提取物安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S25-S45

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1634501

颠茄提取物文献

Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.

J. Neurosci. 35(14) , 5680-92, (2015)

Cholinergic [acetylcholine (ACh)] axons from the basal forebrain innervate olfactory bulb glomeruli, the initial site of synaptic integration in the olfactory system. Both nicotinic acetylcholine rece...

Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives.

Acta. Pharm. 64(2) , 233-45, (2014)

Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroac...

Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in mice.

Pharmacology 93(5-6) , 278-85, (2014)

Methamphetamine abuse may produce cognitive impairment. Baicalein, a bioactive flavonoid, has antioxidative, anti-inflammatory and neuroprotective effects. This study examined the effects of baicalein...

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