二甲嘧酚

二甲嘧酚用途

1.内吸性杀菌剂,可防治黄瓜和甜瓜霜霉病、菊花白粉病等。其盐酸盐均为液剂。

2.嘧啶类内吸性杀菌剂，兼有治疗作用，对各种作物白粉病有特效。主要用于瓜类、蔬菜、甜菜及麦类、橡胶树、柞树等。对木本科植物效果显著，可用0.25%含量土壤施药，药效6周以上，对禾本科植物效果次之，喷雾含量为0.001%～0.1%，当年6～8月施药，防治效果达90%以上。如黄瓜白粉病用0.01%含量喷雾，柞树白粉病用0.1%含量喷雾，防治效果95%。

二甲嘧酚名称

[ CAS 号 ]:
5221-53-4

[ 中文名 ]:
二甲嘧酚

[ 英文名 ]:
4(3H)-Pyrimidinone,5-butyl-2-(dimethylamino)-6-methyl-

[中文别名 ]:

[英文别名 ]:

Caswell No. 128A
EINECS 226-021-7
Dimethirimol
PP 675
Melkeb
Dimethyrimol [ISO-French]
Dimethirimol [BSI:ISO]
5-butyl-2-(dimethylamino)-6-methylpyrimidin-4-ol
5-Butyl-2-dimethylamino-6-methylpyrimidin-4-ol
Methyrimol

二甲嘧酚物理化学性质

[ 密度 ]:
1.07g/cm3

[ 沸点 ]:
296.1ºC at 760mmHg

[ 熔点 ]:
103℃

[ 分子式 ]:
C₁₁H₁₉N₃O

[ 分子量 ]:
209.28800

[ 闪点 ]:
132.9ºC

[ 精确质量 ]:
209.15300

[ PSA ]:
49.25000

[ LogP ]:
1.89920

[ 折射率 ]:
1.536

[ 储存条件 ]:
库房通风低温干燥

二甲嘧酚MSDS

详细MSDS(安全技术说明书)

二甲嘧酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW6025000

CHEMICAL NAME :: 4-Pyrimidinol, 5-butyl-2-dimethylamino-6-methyl-

CAS REGISTRY NUMBER :: 5221-53-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H19-N3-O

MOLECULAR WEIGHT :: 209.33

WISWESSER LINE NOTATION :: T6N CNJ BN1&1 DQ E4 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 219,1160,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,79,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,293,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,293,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,423,1971

二甲嘧酚安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
21-52

[ 安全声明 (欧洲) ]:
36/37

[ 海关编码 ]:
2933599018

二甲嘧酚制备

1.由硫脲与硫酸二甲酯反应,生成物与二甲胺反应,然后再与2-丁基乙酰乙酸乙酯进行闭环,即制得本品。

2.N,N-二甲基胍硫酸盐的制备由尿素（40g）和硫酸二甲酯（210g）于40℃反应3h，然后升温至55～60℃，再冷至40℃反应4h，得甲基异脲硫酸盐备用。将甲基异脲硫酸盐27g加入反应瓶中，于10℃以下滴加40%二甲胺水溶液59g，升温至50℃，保温反应3h，蒸去水分13mL。反应液经浓缩后得晶体，干重12.5g。

3.2-正丁基乙酰乙酸乙酯的制备将小片金属钠13g陆续加入到250mL无水乙醇中，加毕后反应30min。然后一次加入乙酰乙酸乙酯65g，升温至80℃，滴加溴代正丁烷75g，反应物渐变为浅黄色乳状液，在滴加的同时有晶体析出，pH值9～10，反应时间10h，终点狆犎值7～8，静置过夜，倒出上层清液，再将底层溴化钠过滤，取少许无水乙醇洗涤溴化钠，合并洗液，减压蒸馏制得。

4.甲菌定的合成将4.6g小块金属钠陆续投入到120mL无水甲醉中，在搅拌下加入干燥的二甲基肌硫酸盐0.lmol，回流30 min后，加入正丁基乙醚乙酸乙酷0.2mol，于66℃反应20h左右，反应终，点pH值7-8，冷却，用冰酷酸中和至pH值7，过滤，滤液以二氯甲烷萃取_p次，合并萃取液，加无水硫酸钠过夜，过滤，脱洛，得甲菌定。

二甲嘧酚海关

[ 海关编码 ]: 2933599018

[ 中文概述 ]:
2933599018 二甲嘧酚,乙嘧酚,乙嘧酚磺酸酯。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933599018 5-butyl-2-(ethylamino)-6-methylpyrimidin-4-yl dimethylsulfamate