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L-半胱氨酸盐酸盐(无水物)

L-半胱氨酸盐酸盐(无水物)用途

L-Cysteine hydrochloride 是一种条件必需氨基酸,是硫化氢 (H2S)、谷胱甘肽和牛磺酸等生物活性分子的前体。L-Cysteine hydrochloride 能抑制胃饥饿素,降低啮齿动物和人类的食欲。

L-半胱氨酸盐酸盐(无水物)名称

[ CAS 号 ]:
52-89-1

[ 中文名 ]:
L-半胱氨酸盐酸盐无水物

[ 英文名 ]:
L-Cysteine hydrochloride anhydrous

[中文别名 ]:

[英文别名 ]:

EINECS 200-157-7
l-Cys hydrochloride
MFCD00064553
(R)-2-Amino-3-mercaptopropanoic acid hydrochloride
L-Cysteine hydrochloride
Cysteine, hydrochloride, L-
L-Cysteine hydrochloride (1:1)
L-Cysteine, hydrochloride (1:1)
QVYZ1SH &&L or R Form HCl
(R)-(+)-Cysteine hydrochloride

L-半胱氨酸盐酸盐(无水物)生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.

L-半胱氨酸盐酸盐(无水物)物理化学性质

[ 沸点 ]:
293.9ºC at 760 mmHg

[ 熔点 ]:
140-142ºC

[ 分子式 ]:
C₃H₈ClNO₂S

[ 分子量 ]:
157.619

[ 闪点 ]:
131.5ºC

[ 精确质量 ]:
156.996429

[ PSA ]:
102.12000

[ LogP ]:
0.83040

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
室温

L-半胱氨酸盐酸盐(无水物)MSDS

L-半胱氨酸盐酸盐(无水物)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA2275000

CHEMICAL NAME :: Cysteine, hydrochloride, L-

CAS REGISTRY NUMBER :: 52-89-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C3-H7-N-O2-S.Cl-H

MOLECULAR WEIGHT :: 157.63

WISWESSER LINE NOTATION :: SH1YZVQ &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 771 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 2 gm/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81863 No. of Facilities: 114 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6426 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81863 No. of Facilities: 492 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 7343 (estimated) No. of Female Employees: 5313 (estimated)

L-半胱氨酸盐酸盐(无水物)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
HA2275000

[ 海关编码 ]:
2930909090

L-半胱氨酸盐酸盐(无水物)合成路线

L-半胱氨酸盐酸盐(无水物)上下游产品

L-半胱氨酸盐酸盐(无水物)上游产品

L-半胱氨酸盐酸盐(无水物)下游产品

L-半胱氨酸盐酸盐(无水物)制备

1.将胱氨酸溶于稀盐酸中，过滤加入锡粒升温回流。将还原液用水稀释，移去剩余锡粒，通过硫化氢使饱和，过滤，滤渣用少量水洗，将洗液、滤液合并，减压浓缩，冷却结晶，干燥得盐酸L-半胱氨酸。

2. 由毛发中所含的α -角蛋白水解可得胱氨酸，再经化学还原或电解还原成半胱氨酸，再加盐酸成盐。

L-半胱氨酸盐酸盐(无水物)海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-半胱氨酸盐酸盐(无水物)文献

Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.

J. Med. Microbiol. 63(Pt 12) , 1663-9, (2014)

The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident pro...

Quantification of 3-MCPD and its mercapturic metabolite in human urine: validation of an LC-MS-MS method and its application in the general population.

Anal. Bioanal. Chem 407 , 4823-7, (2015)

A new method for the simultaneous quantitative determination in human urine of 3-monochloropropane-1,2-diol (3-MCPD), a toxic food contaminant, and its metabolite, 2,3-dihydroxypropyl mercapturic acid...

In situ hydrogen, acetone, butanol, ethanol and microdiesel production by Clostridium acetobutylicum ATCC 824 from oleaginous fungal biomass.

Anaerobe 34 , 125-31, (2015)

An in situ batch fermentation technique was employed for biohydrogen, acetone, butanol, ethanol and microdiesel production from oleaginous fungal biomass using the anaerobic fermentative bacterium Clo...

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