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8-溴鸟嘌呤3‘,5’-环一磷酸钠盐

用途

8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物,是一种 PKG 激活剂,可显着抑制 Ca2+ 宏观电流并损害高 K+ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有镇痛作用。

名称

[ CAS 号 ]:
51116-01-9

[ 中文名 ]:
8-溴鸟苷3,5-环磷酸钠盐

[ 英文名 ]:
8-Br-cGMP(8-Bromo-cGMP)

[英文别名 ]:

8-Br-cGMP 8-Bromo-cyclic GMP
EINECS 256-993-8
sodium 8-bromo-3',5'-cyclic GMP
MFCD00070128

生物活性

[ 描述 ]:

8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物,是一种 PKG 激活剂,可显着抑制 Ca2+ 宏观电流并损害高 K+ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有镇痛作用。

[ 靶点 ]

PKG, Ca2+[1]

[参考文献]

[1]. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301.

[2]. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50.

物理化学性质

[ 密度 ]:
2.96 g/cm3

[ 沸点 ]:
794.3ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₀BrN₅NaO₇P

[ 分子量 ]:
446.083

[ 闪点 ]:
434.2ºC

[ 精确质量 ]:
444.939880

[ PSA ]:
187.45000

[ LogP ]:
0.25780

[ 储存条件 ]:
-20°C，密封，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.

PLoS ONE 10 , e0134876, (2015)

Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c...

Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.

Br. J. Pharmacol. 171(24) , 5858-69, (2014)

Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadi...

Platelet-derived HMGB1 is a critical mediator of thrombosis.

J. Clin. Invest. 125 , 4638-54, (2015)

Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular patt...

更多文献

8-溴鸟嘌呤3‘,5’-环一磷酸钠盐

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

文献

推荐生产厂家/供应商：

热门化合物

8-溴鸟嘌呤3‘,5’-环一磷酸 钠盐

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

文献

推荐生产厂家/供应商：

热门化合物

8-溴鸟嘌呤3‘,5’-环一磷酸钠盐