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高哌嗪

高哌嗪用途

【用途一】
有机、医药合成中间体，可用于合成盐酸法舒地尔。

高哌嗪名称

[ CAS 号 ]:
505-66-8

[ 中文名 ]:
高哌嗪

[ 英文名 ]:
Homopiperazine

[中文别名 ]:

[英文别名 ]:

hexahydro-1H-1,4-diazepine
EINECS 208-016-1
1,4-diazacycloheptane
High-piperazine
hexahydro-4H-1,4-diazepine
hexahydro-1,4-diazepine
1,4-Diazepane
Homopiperazine
HOJNEYSUCKLEEXTRACT
HPRZ

高哌嗪物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
169.0±8.0 °C at 760 mmHg

[ 熔点 ]:
38-40 °C(lit.)

[ 分子式 ]:
C₅H₁₂N₂

[ 分子量 ]:
100.162

[ 闪点 ]:
64.4±0.0 °C

[ 精确质量 ]:
100.100044

[ PSA ]:
24.06000

[ LogP ]:
-0.48

[ 外观性状 ]:
白色固体(30℃)或无色粘性液体(30℃和以上)

[ 蒸汽压 ]:
1.6±0.3 mmHg at 25°C

[ 折射率 ]:
1.425

[ 储存条件 ]:
存放于惰性气体之中;避免空气,湿气 (吸湿)

高哌嗪MSDS

高哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HM3850000

CHEMICAL NAME :: 1H-1,4-Diazepine, hexahydro-

CAS REGISTRY NUMBER :: 505-66-8

BEILSTEIN REFERENCE NO. :: 0102711

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H12-N2

MOLECULAR WEIGHT :: 100.19

WISWESSER LINE NOTATION :: T7M DMTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,882,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,882,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1050 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

高哌嗪安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H311-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R21;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3259 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
HM3850000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2942000000

高哌嗪合成路线

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高哌嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

高哌嗪文献

Orthovanadate-Induced Vasoconstriction of Rat Mesenteric Arteries Is Mediated by Rho Kinase-Dependent Inhibition of Myosin Light Chain Phosphatase.

Biol. Pharm. Bull. 38 , 1809-16, (2015)

Orthovanadate (OVA), a protein tyrosine phosphatase inhibitor, induces vasoconstriction in a Rho kinase-dependent manner. The aim of this study was to determine the mechanism underlying OVA-induced va...

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高哌嗪