BETA-雌二醇 3-硫酸钠盐

BETA-雌二醇 3-硫酸钠盐用途

17β-雌二醇硫酸盐(钠),也称为β-雌二醇3-硫酸盐钠盐,是一种神经活性类固醇[1][2]。

BETA-雌二醇 3-硫酸钠盐名称

[ CAS 号 ]:
4999-79-5

[ 中文名 ]:
BETA-雌二醇 3-硫酸钠盐

[ 英文名 ]:
17-Beta-Estradiol-3-O-Sulfate Sodium

[英文别名 ]:

b-Estradiol 3-sulfate sodium salt
17BETA-ESTRADIOL 3-SULFATE SODIUM
17BETA-ESTRADIOL 3-SULFATE SODIUM SALT
SODIUM 17B-ESTRADIOL 3-SULFATE
oestradiol 3-sulfate,sodium salt
17B-estradiol 3-sulfate sodium
17Beta-Estradiol 3-O-Sulfate Sodium Salt

BETA-雌二醇 3-硫酸钠盐生物活性

[ 描述 ]:

17β-雌二醇硫酸盐(钠),也称为β-雌二醇3-硫酸盐钠盐,是一种神经活性类固醇[1][2]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[体外研究]

17β-硫酸雌二醇(钠)是一种神经活性类固醇[1][2]。

[参考文献]

[1]. Li W, et al. Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther. 2007;323(1):236-247.

[2]. Schneider C, et al. A novel enzyme-linked immunosorbent assay for ethynylestradiol using a long-chain biotinylated EE2 derivative. Steroids. 2004;69(4):245-253.

BETA-雌二醇 3-硫酸钠盐物理化学性质

[ 分子式 ]:
C₁₈H₂₃NaO₅S

[ 分子量 ]:
374.427

[ 精确质量 ]:
374.116394

[ PSA ]:
95.04000

[ LogP ]:
3.82340

BETA-雌二醇 3-硫酸钠盐安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H332-H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

BETA-雌二醇 3-硫酸钠盐合成路线

详细合成路线

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BETA-雌二醇 3-硫酸钠盐文献

Sulfotransferase 2A1 forms estradiol-17-sulfate and celecoxib switches the dominant product from estradiol-3-sulfate to estradiol-17-sulfate.

J. Steroid Biochem. Mol. Biol. 96(5) , 367-74, (2005)

Using recombinant sulfotransferases (SULTs) expressed in E. coli, beta-estradiol (E2) sulfonation was examined to determine which SULT enzyme is responsible for producing E2-17-sulfate (E2-17-S). SULT...

Steroid sulphate secretion by the human ovary in vitro: influence of gonadotrophins, cyclofenil and clomiphene.

J. Steroid Biochem. 13(12) , 1401-6, (1980)

[Evidence, in vitro, of estrone and estradiol-17 beta 3-sulfoconjugate hydrolysis in the uterus of pregnant guinea pigs].

C. R. Seances. Acad. Sci. III. 292(9) , 609-12, (1981)

The metabolism, in vitro, of [6,7-3H]-oestrone-3-sulfate and [6,7-3H]-oestradiol-17beta-3-sulfate by the uteri of pregnant female Guinea-Pigs has been studied using 900 g supernatants. A hydrolysis of...

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