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克罗米通

克罗米通用途

Crotamiton既作为杀疥螨剂 (治疗疥疮),又作为一般止痒剂, 是一种处方洗液, 涂满整个身体, 除去疥疮寄生虫。

克罗米通名称

[ CAS 号 ]:
483-63-6

[ 中文名 ]:
克罗米通

[ 英文名 ]:
Crotamiton

[中文别名 ]:

[英文别名 ]:

2-Butenamide, N-ethyl-N-(2-methylphenyl)-, (2E)-
N-Ethyl-o-Crotonotoluidine (Crotamiton)
N-Ethyl-o-crotonotoluidide,Crotamiton
(2E)-N-Ethyl-N-(2-methylphenyl)-2-butenamide
N-Ethyl-o-crotonotoluidide
(2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide
MFCD00026989
N-ethylcrotono-o-toluidide
Crotamiton
EINECS 207-596-3

克罗米通生物活性

[ 描述 ]:

Crotamiton既作为杀疥螨剂 (治疗疥疮),又作为一般止痒剂, 是一种处方洗液, 涂满整个身体, 除去疥疮寄生虫。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[相关活性小分子]

克罗米通物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
282.7±19.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₇NO

[ 分子量 ]:
203.280

[ 闪点 ]:
115.5±12.7 °C

[ 精确质量 ]:
203.131012

[ PSA ]:
20.31000

[ LogP ]:
3.10

[ 外观性状 ]:
浅黄色 VISCID 液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
室温

克罗米通MSDS

详细MSDS(安全技术说明书)

克罗米通毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ7000000

CHEMICAL NAME :: o-Crotonotoluidide, N-ethyl-

CAS REGISTRY NUMBER :: 483-63-6

BEILSTEIN REFERENCE NO. :: 3275497

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H17-N-O

MOLECULAR WEIGHT :: 203.31

WISWESSER LINE NOTATION :: 2U1VN2&R B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,35,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,35,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1393 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

克罗米通安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GQ7000000

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