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多根乌头碱

多根乌头碱用途

Karacoline 是在植物 Aconitum kusnezoffii 中发现的二萜生物碱,能通过 NF-κB 信号通路减少椎间盘退变中细胞外基质的降解。

多根乌头碱名称

[ CAS 号 ]:
39089-30-0

[ 中文名 ]:
多根乌头碱

[ 英文名 ]:
Karacoline

[英文别名 ]:

Karacoline
Karakoline

多根乌头碱生物活性

[ 描述 ]:

Karacoline 是在植物 Aconitum kusnezoffii 中发现的二萜生物碱,能通过 NF-κB 信号通路减少椎间盘退变中细胞外基质的降解。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. XiaoliZhou, et al. Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway. Journal of Pharmaceutical Analysis, 2019.

多根乌头碱物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
540.2±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₅NO₄

[ 分子量 ]:
377.518

[ 闪点 ]:
280.5±30.1 °C

[ 精确质量 ]:
377.256622

[ PSA ]:
73.16000

[ LogP ]:
-0.26

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.623

[ 储存条件 ]:
2-8°C，密封，干燥

多根乌头碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5569480

CHEMICAL NAME :: Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1-alpha,14-alpha,16-beta)-

CAS REGISTRY NUMBER :: 39089-30-0

LAST UPDATED :: 199412

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H35-N-O4

MOLECULAR WEIGHT :: 377.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 298 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

多根乌头碱安全信息

[ RTECS号 ]:
AR5569480