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半胱胺S-磷酸盐 钠盐

半胱胺S-磷酸盐 钠盐用途

半胱胺S-磷酸(半胱氨酸)钠可通过人碱性磷酸酶水解成半胱氨。半胱胺是研究肾病性半胱氨酸病的口服活性剂和抗氧化剂[1][2]。

半胱胺S-磷酸盐 钠盐名称

[ CAS 号 ]:
3724-89-8

[ 中文名 ]:
半胱胺S-磷酸盐 钠盐

[ 英文名 ]:
Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

[中文别名 ]:

[英文别名 ]:

半胱胺S-磷酸盐 钠盐生物活性

[ 描述 ]:

半胱胺S-磷酸(半胱氨酸)钠可通过人碱性磷酸酶水解成半胱氨。半胱胺是研究肾病性半胱氨酸病的口服活性剂和抗氧化剂[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 代谢疾病

[参考文献]

[1]. Gainer AL, et al. Cysteamine S-phosphate hydrolysis by pure human alkaline phosphatases and by sera from patients with lymphoproliferative disorders. Cancer Res. 1982 Sep;42(9):3507-9.

[2]. Besouw M, et al. Cysteamine: an old drug with new potential. Drug Discov Today. 2013 Aug;18(15-16):785-92.

半胱胺S-磷酸盐 钠盐物理化学性质

[ 密度 ]:
1.597g/cm3

[ 沸点 ]:
384.2ºC at 760mmHg

[ 熔点 ]:
220ºC (dec.)(lit.)

[ 分子式 ]:
C2H7NNaO3PS

[ 分子量 ]:
179.11000

[ 闪点 ]:
186.2ºC

[ 精确质量 ]:
178.97800

[ PSA ]:
121.49000

[ LogP ]:
0.90950

[ 储存条件 ]:
库房通风低温干燥

半胱胺S-磷酸盐 钠盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TE6483500
CHEMICAL NAME :
Phosphorothioic acid, S-(2-aminoethyl) ester, monosodium salt
CAS REGISTRY NUMBER :
3724-89-8
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C2-H7-N-O3-P-S.Na
MOLECULAR WEIGHT :
179.12
WISWESSER LINE NOTATION :
Z2SPQO&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
555 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
505 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1433 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
806 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1003 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
358 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

半胱胺S-磷酸盐 钠盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TE6483500

半胱胺S-磷酸盐 钠盐文献

A comparison of the effectiveness of cysteamine and phosphocysteamine in elevating plasma cysteamine concentration and decreasing leukocyte free cystine in nephropathic cystinosis.

Pediatr. Res. 23(6) , 616-20, (1988)

Cysteamine (beta-mercaptoethylamine, MEA) is currently used to treat children with nephropathic cystinosis. In this study MEA was compared to phosphocysteamine (MEAP), a phosphorothioester that tastes...

The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire.

Pediatr. Nephrol. 9(6) , 685-9, (1995)

Fifty-nine patients with cystinosis were treated with cysteamine or phosphocysteamine in the United Kingdom up to May 1990. Treatment was started at a median age of 3.2 years (range 0.6-24.8 years) an...

Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis.

J. Inherit. Metab. Dis. 35(5) , 847-57, (2012)

Infantile neuronal ceroid lipofuscinosis (INCL) is a profoundly neurodegenerative disease of children caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). There is c...


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价格：
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