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2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐用途

4-甲基组胺(盐酸)是组胺4受体(H4R)的有效激动剂。4-甲基组胺(二氢氯化物)具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1]。

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐名称

[ CAS 号 ]:
36376-47-3

[ 中文名 ]:
2-(4-甲基-1H-咪唑-5-基)乙胺双盐酸盐

[ 英文名 ]:
4-Methylhistamine dihydrochloride

[英文别名 ]:

5-metilistamina diclorinato
5-Methylhistamine dihydrochloride
5-Methyl-1H-imidazole-4-ethanamine dihydrochloride
2-methylhistamine dihydrochloride
5-metilistamina dicloridrato
4-Methylhistamine dihydrochloride

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐生物活性

[ 描述 ]:

4-甲基组胺(盐酸)是组胺4受体(H4R)的有效激动剂。4-甲基组胺(二氢氯化物)具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 组胺受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

histamine 4 receptor[1]

[参考文献]

[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐物理化学性质

[ 密度 ]:
1.1g/cm3

[ 沸点 ]:
345ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₃Cl₂N₃

[ 分子量 ]:
198.09400

[ 闪点 ]:
189.3ºC

[ 精确质量 ]:
197.04900

[ PSA ]:
54.70000

[ LogP ]:
2.52360

[ 折射率 ]:
1.558

[ 储存条件 ]:
2-8°C

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3505800

CHEMICAL NAME :: Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 36376-47-3

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H11-N3.2Cl-H

MOLECULAR WEIGHT :: 198.12

WISWESSER LINE NOTATION :: T5M CNJ D2Z E1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 991 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pleural effusion

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933290090

2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐合成路线

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2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%