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S-(5′-腺苷)-L-甲硫氨酸碘盐

S-(5′-腺苷)-L-甲硫氨酸碘盐用途

S-(5'-腺苷基)-L-甲硫氨酸碘(S-腺苷基-L-甲硫氨酸碘)是一种重要的甲基供体,存在于所有生物中[1]。

S-(5′-腺苷)-L-甲硫氨酸碘盐名称

[ CAS 号 ]:
3493-13-8

[ 中文名 ]:
S-腺苷基-L-蛋氨碘盐

[ 英文名 ]:
5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE

[中文别名 ]:

[英文别名 ]:

EINECS 222-486-5
SAM iodide salt
S-(5'-ADENOSYL)-L-METHIONINE IODIDE
S-ADENOSYL METHIONINE IODIDE SALT
adomet
MFCD00043192
S-(5'-deoxy-5'-adenosyl)methionine iodide
S-adenosylmethionine
SAM-E IODIDE SALT
AdoMet,SAM

S-(5′-腺苷)-L-甲硫氨酸碘盐生物活性

[ 描述 ]:

S-(5'-腺苷基)-L-甲硫氨酸碘(S-腺苷基-L-甲硫氨酸碘)是一种重要的甲基供体,存在于所有生物中[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

通过提供甲基,涉及高氯酸提取的sues被转化为S-腺苷-L-同型半胱氨酸,由She等人报道。SAM和(SAH)的分离[1]。

[参考文献]

[1]. W Wang, et al. Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations. J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):59-65.

S-(5′-腺苷)-L-甲硫氨酸碘盐物理化学性质

[ 分子式 ]:
C₁₅H₂₃IN₆O₅S

[ 分子量 ]:
526.35000

[ 精确质量 ]:
526.05000

[ PSA ]:
207.93000

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 100 mg/mL

S-(5′-腺苷)-L-甲硫氨酸碘盐MSDS

S-(5′-腺苷)-L-甲硫氨酸碘盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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S-(5′-腺苷)-L-甲硫氨酸碘盐文献

In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist.

J. Pharm. Biomed. Anal. 94 , 36-44, (2014)

Structural modification of the GluN2B selective NMDA receptor antagonist ifenprodil led to the 3-benzazepine WMS-1410 with similar GluN2B affinity but higher receptor selectivity. Herein the in vitro ...

Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.

J. Biol. Chem. 287 , 1426-1434, (2012)

In the malarial parasite Plasmodium falciparum, a multifunctional phosphoethanolamine methyltransferase (PfPMT) catalyzes the methylation of phosphoethanolamine (pEA) to phosphocholine for membrane bi...

DNA methyltransferases: mechanistic models derived from kinetic analysis.

Crit. Rev. Biochem. Mol. Biol. 47(2) , 97-193, (2012)

The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form...

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