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甲硫米特

甲硫米特用途

Metiamide是组胺H2受体拮抗剂。

甲硫米特名称

[ CAS 号 ]:
34839-70-8

[ 中文名 ]:
甲硫米特

[ 英文名 ]:
Metiamide

[英文别名 ]:

metiamide
Metiamidum
Metiamida
SK&Methiamide

甲硫米特生物活性

[ 描述 ]:

Metiamide是组胺H2受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 内分泌

[参考文献]

[1]. Alexandra Kikonyogo ,Regina Pietruszko, Cimetidine and Other H2-Receptor Antagonists as Inhibitors of Human E3 Aldehyde Dehydrogenase. Molecular Pharmacology 1997; 52: 2267-271.

[2]. Hendrik Preuss, Prasanta Ghorai1, Anja Kraus, Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors. JPET 2007 vol. 321no. 3 983-995.

[相关活性小分子]

甲硫米特物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
463.0±55.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₆N₄S₂

[ 分子量 ]:
244.380

[ 闪点 ]:
233.8±31.5 °C

[ 精确质量 ]:
244.081635

[ PSA ]:
110.13000

[ LogP ]:
0.65

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
2-8℃

甲硫米特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT7750000

CHEMICAL NAME :: Urea, 1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)et hyl)-2-thio-

CAS REGISTRY NUMBER :: 34839-70-8

LAST UPDATED :: 198703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H16-N4-S2

MOLECULAR WEIGHT :: 244.41

WISWESSER LINE NOTATION :: T5M CNJ D1S2MYUS&M1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1493 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2642 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 umol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

甲硫米特安全信息

[ 海关编码 ]:
2933290090

甲硫米特合成路线

详细合成路线

甲硫米特上下游产品

甲硫米特上游产品

甲硫米特下游产品

甲硫米特海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%